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首页> 外文期刊>Archives of microbiology >Metronidazole resistance and microaerophily in Campylobacter species
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Metronidazole resistance and microaerophily in Campylobacter species

机译：弯曲杆菌种对甲硝唑的耐药性和微需氧性

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Metronidazole is active against most anaerobic organisms and is also used in the treatment of the microaerophilic bacterium Helicobacter pylori. Resistance to metronidazole is uncommon in most anaerobic organisms, but it is increasingly prevalent in H. pylori. Previously we have suggested that metronidazole resistance in H. pylori is inherent in the microaerophilic nature of the organism and therefore would be present in other microaerophiles such as Campylobacter. Short periods of anaerobiosis caused metronidazole-resistant (Mtr(R)) strains of Campylobacter spp. to become sensitive to metronidazole. Under microaerophilic conditions, cultures of the MtrR mutant Campylobacter coli R1 at bacterial cell densities of greater than 10(8) cfu/ml lost viability, whereas no loss in viability was observed in cultures at cell densities of less than 108. The Mtr(S) C. coli strain lost viability at all cell densities. Comparisons of NAD(P)H oxidase activity between MtrS and MtrR strains indicated that the Mtr(S) C. coli strain contained fourfold higher NADH oxidase activity and twofold higher NADPH oxidase activity than did the Mtr(R) Campylobacter strains. These results show that MtrR Campylobacter spp. display resistance characteristics similar to those of H. pylori, suggesting that the resistance mechanism is a phenomenon of the microaerophilic nature of these bacteria. [References: 31]
机译：甲硝唑对大多数厌氧生物具有活性，还用于治疗微需氧细菌幽门螺杆菌。对甲硝唑的抗性在大多数厌氧生物中并不常见，但在幽门螺杆菌中越来越普遍。以前我们曾提出幽门螺杆菌对甲硝唑的耐药性是该微生物的微需氧性所固有的，因此会存在于其他微需氧菌如弯曲杆菌中。短期厌氧菌引起弯曲杆菌属菌株对甲硝唑的耐药（Mtr（R））菌株。对甲硝唑敏感。在微需氧条件下，细菌细胞密度大于10（8）cfu / ml的MtrR突变弯曲杆菌R1的培养物丧失了活力，而细胞密度低于108的培养物中没有观察到活力丧失。大肠杆菌菌株在所有细胞密度下均丧失活力。 MtrS和MtrR菌株之间NAD（P）H氧化酶活性的比较表明，与Mtr（R）弯曲杆菌菌株相比，Mtr（S）大肠杆菌菌株的NADH氧化酶活性和NADPH氧化酶活性高四倍。这些结果表明，MtrR弯曲杆菌属。幽门螺杆菌显示出与幽门螺杆菌相似的耐药特性，表明耐药机制是这些细菌的微需氧性现象。 [参考：31]

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