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首页> 外文期刊>Archives of orthopaedic and trauma surgery. >The efficacy of erythropoietin on acute spinal cord injury. An experimental study on a rat model.
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The efficacy of erythropoietin on acute spinal cord injury. An experimental study on a rat model.

机译：促红细胞生成素对急性脊髓损伤的疗效。大鼠模型的实验研究。

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INTRODUCTION: The accumulated knowledge of erythropoietin (EPO) interaction in neural injury has led to potentially novel therapeutic strategies. Previous experimental studies of recombinant human EPO (rhEPO) administration have shown favorable results after central and peripheral neural injury. In the present study we used the aneurysmal clip model to evaluate the efficacy of two different regimes of rhEPO administration on the functional outcome after severe acute spinal cord injury (ASCI). MATERIALS AND METHODS: Thirty rats were operated on with posterior laminectomy at thoracic 10th vertebra. Spinal cord trauma produced by extradural placement of the aneurysm clip, for 1 min. Animals were divided into three groups; the first group received a low total EPO dose (EPO-L), (2 doses of 1,000 IU each s.c.). The second group was administered the high total EPO dose (EPO-H), (14 doses of 1,000 IU each s.c.), and the third was the Control group, which received normal saline in the same time fashion with EPO-H group. Follow-up was for 6 weeks. Estimation of the functional progress of each rat was calculated using the locomotor rating scale of Basso et al, with a range from 0 to 21. RESULTS: After surgery the animals suffered paraplegia with urinary disturbances. Rats that received EPO demonstrated statistically significant functional improvement compared to the Control group, throughout study interval. On the last follow-up at 6 weeks the EPO-L rats achieved a mean score 17.3 +/- 1.15, the EPO-H 14.7 +/- 1.82, and the control group 8.2 +/- 0.78. Comparison between the two EPO groups reveals superior final outcome of the group treated with lower total dose. CONCLUSION: Our study supports current knowledge, that EPO administration has a positive effect on functional recovery after experimental ASCI. These data reflect the positive impact of EPO on the pathophysiologic cascade of secondary neural damage. However, we observed a dose-related effect on functional recovery. Interestingly, large doses do not seem to favor the neurological recovery as lower doses do.
机译：简介：神经损伤中促红细胞生成素（EPO）相互作用的累积知识已导致潜在的新型治疗策略。先前进行的重组人EPO（rhEPO）给药的实验研究表明，在中枢神经系统和周围神经损伤后，治疗效果良好。在本研究中，我们使用动脉瘤夹模型评估两种不同方案的rhEPO给药对严重急性脊髓损伤（ASCI）后功能结局的疗效。材料与方法：30只大鼠在胸椎第10椎板进行了后椎板切除术。硬膜外放置动脉瘤夹产生的脊髓损伤，持续1分钟。动物分为三组。第一组的总EPO剂量很低（EPO-L）（2剂量每秒钟1,000 IU）。第二组接受高总EPO剂量（EPO-H）（14剂量每秒钟1,000 IU），第三组为对照组，与EPO-H组同时接受生理盐水。随访6周。使用Basso等人的运动自评量表计算每只大鼠的功能进展估计值，范围为0到21。结果：手术后动物遭受了截瘫并伴有泌尿系统疾病。在整个研究期间，与对照组相比，接受EPO的大鼠表现出统计学上显着的功能改善。在6周的最后一次随访中，EPO-L大鼠的平均评分为17.3 +/- 1.15，EPO-H为14.7 +/- 1.82，对照组为8.2 +/- 0.78。两个EPO组之间的比较显示，用较低的总剂量治疗组的最终结果更好。结论：我们的研究支持当前的知识，即EPO给药对实验性ASCI后的功能恢复具有积极作用。这些数据反映了EPO对继发性神经损伤的病理生理级联的积极影响。但是，我们观察到功能恢复与剂量有关。有趣的是，大剂量似乎不像低剂量那样有利于神经系统恢复。

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