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Comparison of the toxicity of aluminum oxide nanorods with different aspect ratio

机译：不同长径比氧化铝纳米棒的毒性比较

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Aluminum oxide nanoparticles are listed among 14 high-priority nanomaterials published by the Organization for Economic Co-operation and Development, but limited information is available on their potential hazards. In this study, we compared the toxicity of two different aluminum oxide nanorods (AlNRs) commercially available in vivo and in vitro. Considering aspect ratio, one was 6.2 +/- A 0.6 (long-AlNRs) and the other was 2.1 +/- A 0.4 (short-AlNRs). In mice, long-AlNRs induced longer and stronger inflammatory responses than short-AlNRs, and the degree reached the maximum on day 7 for both types and decreased with time. In addition, in vitro tests were performed on six cell lines derived from potential target organs for AlNPs, HEK-293 (kidney), HACAT (skin), Chang (liver), BEAS-2B (lung), T98G (brain), and H9C2 (heart), using MTT assay, ATP assay, LDH release, and xCELLigence system. Long-AlNRs generally produced stronger toxicity than short-AlNRs, and HEK-293 cells were the most sensitive for both AlNRs, followed by BEAS-2B cells, although results from 4 kinds of toxicity tests conflicted among the cell lines. Based on these results, we suggest that toxicity of AlNRs may be related to aspect ratio (and resultant surface area). Furthermore, novel in vitro toxicity testing methods are needed to resolve questionable results caused by the unique properties of nanoparticles.
机译：经济合作与发展组织（OECD）发布了14种高优先级纳米材料中的氧化铝纳米颗粒，但有关其潜在危害的信息有限。在这项研究中，我们比较了体内和体外市售的两种不同氧化铝纳米棒（AlNRs）的毒性。考虑长宽比，一个为6.2 +/- A 0.6（长AlNRs），另一个为2.1 +/- A0.4（短AlNRs）。在小鼠中，长AlNRs引起的炎症反应比短AlNRs更长和更强，两种类型的程度在第7天均达到最大值，并随时间降低。另外，对源自AlNPs，HEK-293（肾脏），HACAT（皮肤），Chang（肝脏），BEAS-2B（肺），T98G（脑）和ANP的潜在靶器官的六种细胞系进行了体外测试。 H9C2（心脏），使用MTT分析，ATP分析，LDH释放和xCELLigence系统。长AlNRs产生的毒性通常比短AlNRs强，HEK-293细胞对两种AlNRs最敏感，其次是BEAS-2B细胞，尽管4种毒性试验的结果在细胞系之间存在冲突。根据这些结果，我们认为AlNRs的毒性可能与长宽比（以及产生的表面积）有关。此外，需要新的体外毒性测试方法来解决由纳米颗粒的独特性质引起的可疑结果。

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