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首页> 外文期刊>Archives of virology >Evolutionary pattern of influenza B viruses based on the HA and NS genes during 1940 to 1999: origin of the NS genes after 1997.
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Evolutionary pattern of influenza B viruses based on the HA and NS genes during 1940 to 1999: origin of the NS genes after 1997.

机译：1940年至1999年间基于HA和NS基因的乙型流感病毒的进化模式：1997年后NS基因的起源。

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摘要

Phylogenetic analysis was carried out for genes encoding hemagglutinin (HA) (24 new and 25 previously reported sequences) and nonstructural proteins (NS) (22 new and 14 previously reported sequences) of influenza B virus isolates obtained from 1940 to 1999. Two antigenically and genetically distinct HA lineages are presently known to exist. Divergence into these two lineages was estimated to have occurred around 1969. Phylogenetic analysis of NS genes revealed that their phylogenetic relationships were not linked to the two HA lineages but suggested that reassortment of viral genes between the viruses of two HA lineages had occurred. In addition two distinct NS lineages which were not linked to the two HA lineages were observed. Viruses isolated after 1997 formed their own lineage in combination with B/Houston/84 while other virus isolates obtained from 1973 to 1995 comprised the other NS lineage.
机译：对从1940年至1999年获得的B型流感病毒分离株的编码血凝素（HA）（24个新的和25个以前报道的序列）和非结构蛋白（NS）（22个新的和14个以前报道的序列）的基因进行了系统发育分析。目前已知存在遗传上不同的HA谱系。估计在这两个谱系中出现了分歧，估计发生在1969年左右。对NS基因的系统进化分析表明，它们的系统发育关系与这两个HA谱系没有联系，但表明在两个HA谱系的病毒之间发生了病毒基因的重配。另外，观察到未与两个HA谱系连锁的两个不同的NS谱系。 1997年后分离出的病毒与B / Houston / 84结合形成了自己的谱系，而从1973年至1995年获得的其他病毒分离株则包含了其他NS谱系。

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