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首页> 外文期刊>Archives of Toxicology >Prepubertal exposure to commercial formulation of the herbicide glyphosate alters testosterone levels and testicular morphology.
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Prepubertal exposure to commercial formulation of the herbicide glyphosate alters testosterone levels and testicular morphology.

机译：青春期前暴露于除草剂草甘膦的商业配方会改变睾丸激素水平和睾丸形态。

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Glyphosate is a herbicide widely used to kill weeds both in agricultural and non-agricultural landscapes. Its reproductive toxicity is related to the inhibition of a StAR protein and an aromatase enzyme, which causes an in vitro reduction in testosterone and estradiol synthesis. Studies in vivo about this herbicide effects in prepubertal Wistar rats reproductive development were not performed at this moment. Evaluations included the progression of puberty, body development, the hormonal production of testosterone, estradiol and corticosterone, and the morphology of the testis. Results showed that the herbicide (1) significantly changed the progression of puberty in a dose-dependent manner; (2) reduced the testosterone production, in semineferous tubules' morphology, decreased significantly the epithelium height (P < 0.001; control = 85.8 +/- 2.8 microm; 5 mg/kg = 71.9 +/- 5.3 microm; 50 mg/kg = 69.1 +/- 1.7 microm; 250 mg/kg = 65.2 +/- 1.3 microm) and increased the luminal diameter (P < 0.01; control = 94.0 +/- 5.7 microm; 5 mg/kg = 116.6 +/- 6.6 microm; 50 mg/kg = 114.3 +/- 3.1 microm; 250 mg/kg = 130.3 +/- 4.8 microm); (4) no difference in tubular diameter was observed; and (5) relative to the controls, no differences in serum corticosterone or estradiol levels were detected, but the concentrations of testosterone serum were lower in all treated groups (P < 0.001; control = 154.5 +/- 12.9 ng/dL; 5 mg/kg = 108.6 +/- 19.6 ng/dL; 50 mg/dL = 84.5 +/- 12.2 ng/dL; 250 mg/kg = 76.9 +/- 14.2 ng/dL). These results suggest that commercial formulation of glyphosate is a potent endocrine disruptor in vivo, causing disturbances in the reproductive development of rats when the exposure was performed during the puberty period.
机译：草甘膦是一种除草剂，广泛用于在农业和非农业景观中杀死杂草。它的生殖毒性与StAR蛋白和芳香酶的抑制有关，后者导致睾丸激素和雌二醇合成的体外减少。目前尚未进行有关青春期前Wistar大鼠生殖发育中这种除草剂作用的体内研究。评估包括青春期的进展，身体发育，睾丸激素，雌二醇和皮质酮的激素产生以及睾丸的形态。结果表明，除草剂（1）以剂量依赖性方式显着改变青春期的进程; （2）减少睾丸激素的产生，以半神经小管的形态显着降低上皮高度（P <0.001;对照= 85.8 +/- 2.8微米; 5 mg / kg = 71.9 +/- 5.3微米; 50 mg / kg = 69.1 +/- 1.7微米; 250 mg / kg = 65.2 +/- 1.3微米）并增加管腔直径（P <0.01;对照= 94.0 +/- 5.7微米; 5 mg / kg = 116.6 +/- 6.6微米; 50 mg / kg = 114.3 +/- 3.1微米; 250 mg / kg = 130.3 +/- 4.8微米）; （4）没有观察到管径的差异; （5）与对照组相比，未检测到血清皮质酮或雌二醇水平的差异，但所有治疗组的睾丸激素血清浓度均较低（P <0.001;对照组= 154.5 +/- 12.9 ng / dL; 5 mg / kg = 108.6 +/- 19.6 ng / dL; 50 mg / dL = 84.5 +/- 12.2 ng / dL; 250 mg / kg = 76.9 +/- 14.2 ng / dL）。这些结果表明，草甘膦的商业制剂是体内有效的内分泌干扰物，当在青春期进行暴露时会引起大鼠生殖发育的紊乱。

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