...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Archives of Toxicology >Chinese herbs nephropathy-associated slimming regimen induces tumours in the forestomach but no interstitial nephropathy in rats.
【24h】

Chinese herbs nephropathy-associated slimming regimen induces tumours in the forestomach but no interstitial nephropathy in rats.

机译：中药肾病相关的减肥方案在前胃中诱发肿瘤，但在大鼠中无间质性肾病。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Chinese herbs nephropathy (CHN), a rapidly progressive interstitial fibrosis of the kidney, has been described in approximately 100 young Belgian women who had followed a slimming regimen containing some Chinese herbs. In 4 patients multifocal transitional cell carcinomas (TCC) were observed. Aristolochic acid (AA), suspected as the causal factor of CHN, is a well known carcinogen but its ability to induce fibrosis has never been demonstrated. The objective of this study was to evaluate the latter using doses of AA, durations of intoxication and delays of sacrifice known to yield tumours in rats. We also tested the hypothesis that a possible fibrogenic role of AA was enhanced by the other components of the slimming regimen. Male and female rats were treated orally with 10 mg isolated AA/kg per day for 5 days/week, or with approximately 0.15 mg AA/ kg per day 5 days/week contained in the herbal powder together with the other components prescribed in the slimming pills for 3 months. The animals were killed respectively 3 and 11 months later. At sacrifice, animals in both groups had developed the expected tumours but not fibrosis of the renal interstitium. Whether the fibrotic response observed in man is due to species and/or strain related differences in the response to AA or to other factors, remains to be determined. Interestingly, despite the addition of fenfluramine and diethylpropion, two drugs incriminated in the development of valvular heart disease, no cardiac abnormalities were observed.
机译：中草药肾病（CHN）是一种快速进行性的肾脏间质纤维化，已有大约100名年轻的比利时女性在使用了一些中草药的减肥方案后进行了描述。在4例患者中观察到多灶性移行细胞癌（TCC）。马兜铃酸（AA）被怀疑是CHN的致病因素，是众所周知的致癌物，但其诱导纤维化的能力从未得到证实。这项研究的目的是通过使用AA的剂量，中毒的持续时间和已知会在大鼠体内产生肿瘤的牺牲时间来评估后者。我们还测试了减肥方案中其他成分增强了AA可能的纤维化作用的假设。雄性和雌性大鼠口服每日10 mg分离的AA / kg，连续5天/周，或以草药粉中包含的瘦身中规定的其他成分口服，每周5天/周，每天约0.15 mg AA / kg丸3个月。 3个月和11个月后分别杀死动物。处死时，两组动物均出现了预期的肿瘤，但未出现肾间质纤维化。在人中观察到的纤维化反应是否是由于对AA或其他因素的反应中与物种和/或菌株相关的差异所致，尚待确定。有趣的是，尽管加入了芬氟拉明和二乙基丙酸，这两种药物均导致瓣膜性心脏病，但未观察到心脏异常。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号