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首页> 外文期刊>Archives of Toxicology >Genotoxicity investigations on nanomaterials.
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Genotoxicity investigations on nanomaterials.

机译：纳米材料的遗传毒性研究。

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This review is based on the lecture presented at the April 2010 nanomaterials safety assessment Postsatellite to the 2009 EUROTOX Meeting and summarizes genotoxicity investigations on nanomaterials published in the open scientific literature (up to 2008). Special attention is paid to the relationship between particle size and positive versus negative outcome, as well as the dependence of the outcome on the test used. Salient conclusions and outstanding recommendations emerging from the information summarized in this review are as follows: recognize that nanomaterials are not all the same; therefore know and document what nanomaterial has been tested and in what form; take nanomaterials specific properties into account; in order to make your results comparable with those of others and on other nanomaterials: use or at least include in your studies standardized methods; use in vivo studies to put in vitro results into perspective; take uptake and distribution of the nanomaterial into account; and in order to become able to make extrapolations to risk for human: learn about the mechanism of nanomaterials genotoxic effects. Past experience with standard non-nanosubstances already had shown that mechanisms of genotoxic effects can be complex and their elucidation can be demanding, while there often is an immediate need to assess the genotoxic hazard. Thus, a practical and pragmatic approach to genotoxicity investigations of novel nanomaterials is the use of a battery of standard genotoxicity testing methods covering a wide range of mechanisms. Application of these standard methods to nanomaterials demands, however, adaptations, and the interpretation of results from the genotoxicity testing of nanomaterials needs additional considerations exceeding those used for standard size materials.
机译：这篇综述基于在2009年EUROTOX会议上在2010年4月卫星材料纳米材料安全性评估上发表的演讲，并总结了公开科学文献中（截至2008年）发表的关于纳米材料的遗传毒性研究。要特别注意颗粒大小与阳性结果与阴性结果之间的关系，以及结果对所用测试的依赖性。从本综述总结的信息中得出的显着结论和杰出建议如下：认识到纳米材料并不完全相同;因此，知道并记录已测试了哪种纳米材料以及以哪种形式存在;考虑纳米材料的特定特性;为了使您的结果与其他纳米材料的结果可比：在研究中使用或至少包括标准化方法;利用体内研究来透视体外结果;考虑到纳米材料的吸收和分布;为了能够推断人类的风险：了解纳米材料的遗传毒性作用机理。过去使用标准非纳米物质的经验已经表明，遗传毒性作用的机制可能很复杂，要求其阐明可能很困难，而经常需要立即评估遗传毒性危害。因此，对新型纳米材料进行遗传毒性研究的一种实用的实用方法是使用一系列涵盖广泛机制的标准遗传毒性测试方法。但是，将这些标准方法应用于纳米材料需要进行修改，并且对纳米材料的遗传毒性测试结果的解释需要超出标准尺寸材料的考虑范围。

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