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首页> 外文期刊>Archives of Toxicology >Protective effects of glutathione on 5-fluorouracil-induced myelosuppression in mice.
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Protective effects of glutathione on 5-fluorouracil-induced myelosuppression in mice.

机译：谷胱甘肽对5-氟尿嘧啶诱导的小鼠骨髓抑制的保护作用。

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The protective effects of glutathione (GSH) administration on myelosuppression induced by 5-fluorouracil (5-FU) were investigated in female BALB/c mice. Animals were allocated to four groups (16 mice/group). GSH was given orally at a dose of 800 mg/kg to groups 3 and 4 for 21 consecutive days (day 0 to day 20). 5-FU was repeatedly administered at a dose of 40 mg/kg to groups 2 and 3 for 1 week (day 7 to day 13) by gavage. Group 3 served as a combined treatment group and group 1 as a non-treated control group. The total observation period was 3 weeks. Body weight was measured once a week. A decrease in body weight due to 5-FU treatment was observed in groups 2 and 3 on day 14. Although the body weight in group 2 had not increased by 1-week after cessation of 5-FU treatment, the value in group 3 markedly recovered. Hematology, total nucleated myelocyte count and histopathology of bone marrow were carried out on day 14 and day 21. In groups 2 and 3, these examinations showed thrombocytopenia, leukopenia, reticulocytopenia and myelosuppression on day 14. However, platelets and bone marrow were less affected in group 3 than in group 2. On day 21, the thrombocytopenia in groups 2 and 3 was resolved. The myelosuppression, leukopenia and reticulocytopenia resolved in group 3, but not in group 2. Although simple microcytic anemia occurred delayed on day 21, it was less severe in group 3 than in group 2. Therefore, GSH may have preventive effects against 5-FU-induced hematopoietic toxicity, and accelerate recovery after cessation of 5-FU treatment.
机译：在雌性BALB / c小鼠中研究了谷胱甘肽（GSH）对5-氟尿嘧啶（5-FU）诱导的骨髓抑制的保护作用。将动物分为四组（每组16只小鼠）。连续21天（第0天至第20天）以800 mg / kg的剂量口服GSH给第3组和第4组。通过管饲法将5-FU以40 mg / kg的剂量重复给药于第2组和第3组，持续1周（第7天至第13天）。第3组为联合治疗组，第1组为未治疗的对照组。总观察期为3周。每周测量一次体重。在第14天，第2组和第3组观察到由于5-FU治疗引起的体重下降。尽管第2组的体重在停止5-FU治疗后的1周内没有增加，但第3组的值明显恢复了。在第14天和第21天进行血液学检查，总有核髓细胞计数和骨髓组织病理学检查。在第2和第3组中，这些检查显示在第14天出现血小板减少，白细胞减少，网状细胞减少和骨髓抑制。但是，血小板和骨髓受到的影响较小与第2组相比，第3组的血小板减少。在第21天，第2和3组的血小板减少症得到解决。第3组的骨髓抑制，白细胞减少和网状细胞减少症得以缓解，而第2组则没有。尽管第21天发生了简单的小细胞性贫血，但与第2组相比，第3组的严重程度较轻。因此，GSH可能对5-FU有预防作用诱导的造血毒性，并在停止5-FU治疗后加速恢复。

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