...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Archives of Toxicology >Induced pluripotent stem cells: a new tool for toxicology screening?
【24h】

Induced pluripotent stem cells: a new tool for toxicology screening?

机译：诱导多能干细胞：毒理学筛查的新工具？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In recent years, stem cells have generated much interest as a potential tool for pharmacological and toxicology screening (CIRM 2008; ABPI 2008), due to various shortcomings of currently utilized assay models based on established cell lines, primary explanted somatic cells and laboratory animals (Cao et al. 2008; Vinoth et al. 2008). In vitro toxicology screening most commonly utilize established cell lines of cancerous/tumorigenic origin, that are highly adapted to in vitro culture conditions after countless passages, and which contain chromosomal and genetic aberrations that render them immortal (Phelps etal. 1996). Such inherent deficiencies make them non-representative of how a normal cell behaves physiologically in vivo. Indeed, it is common knowledge that immortalized transformed cell lines are more robust, proliferates faster, and have much less fastidious nutritional requirements compared to primary somatic cells explanted from living tissues (Phelps et al. 1996).
机译：近年来，由于基于已建立的细胞系，原代移植的体细胞和实验动物的当前使用的测定模型的各种缺陷，干细胞作为药理学和毒理学筛查的潜在工具引起了广泛兴趣（CIRM 2008; ABPI 2008）（ Cao等，2008; Vinoth等，2008）。体外毒理学筛查最常见的方法是利用已建立的癌性/致瘤性细胞系，这些细胞系经过无数次传代后高度适应体外培养条件，并且含有使其不朽的染色体和遗传畸变（Phelps等，1996）。这种固有的缺陷使其无法代表正常细胞在体内的生理行为。确实，众所周知，与从活组织中移植的原代体细胞相比，永生化的转化细胞系更健壮，增殖更快，营养要求低得多。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号