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首页> 外文期刊>Archives of Toxicology >Itai-itai disease is not associated with polymorphisms of the estrogen receptor alpha gene.
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Itai-itai disease is not associated with polymorphisms of the estrogen receptor alpha gene.

机译：Itai-itai疾病与雌激素受体α基因的多态性无关。

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摘要

Itai-itai (or ouch-ouch) disease is a syndrome accompanied by bone mineral disorders, and which may be related to oral cadmium exposure. Itai-itai predominantly affects postmenopausal women with a history of multiple childbirths. Recently, it has been reported that polymorphisms of the estrogen receptor alpha (ERalpha) gene are associated with postmenopausal reduction of bone mineral density in Japanese women. However, estrogen receptors have never been studied in itai-itai disease. In this study, we examined the genotypic distributions of PvuII and XbaI restriction fragment length polymorphisms (RFLPs) of the ERalpha gene in patients with itai-itai disease and compared them with those of control subjects. The RFLPs are represented here as Pp (PvuII) and Xx (XbaI); the capital and small letters signify the absence and presence of restriction sites, respectively. The genotypic distributions of the patient group were: PP, 14.8%; Pp, 55.6%; pp, 29.6%; XX, 7.4%; Xx, 29.6%; and xx, 63.0%. These distributions were similar to those observed for the control groups, hence no pattern of genotypic distribution was observed that could be related to itai-itai disease. We conclude that RFLPs of the ERalpha gene may not be associated with itai-itai disease.
机译：Itai-itai（或ouch-ouch）疾病是伴有骨矿物质疾病的综合征，可能与口服镉暴露有关。 Itai-itai主要影响有多个分娩史的绝经后妇女。最近，据报道，雌激素受体α（ERalpha）基因的多态性与日本女性绝经后骨矿物质密度的降低有关。然而，从未在伊塔伊塔伊病中研究雌激素受体。在这项研究中，我们检查了伊塔伊塔伊病患者ERalpha基因的PvuII和XbaI限制性片段长度多态性（RFLP）的基因型分布，并将其与对照组进行比较。 RFLP在这里表示为Pp（PvuII）和Xx（XbaI）;大写字母和小写字母分别表示不存在限制位点。患者组的基因型分布为：PP，14.8％; pp，55.6％; pp，29.6％; XX，7.4％; Xx，29.6％;和xx，占63.0％。这些分布与对照组所观察到的相似，因此未观察到可能与伊塔伊塔伊病相关的基因型分布模式。我们得出结论，ERalpha基因的RFLP可能与伊塔伊塔伊病无关。

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