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首页> 外文期刊>Archives of Toxicology >No relationship exists between itai-itai disease and TA repeat polymorphisms of the estrogen receptor alpha gene.
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No relationship exists between itai-itai disease and TA repeat polymorphisms of the estrogen receptor alpha gene.

机译:Itai-itai病与雌激素受体α基因的TA重复多态性之间没有关系。

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摘要

Itai-itai (ouch-ouch) disease is a syndrome accompanied by bone mineral disorders that may be related to oral cadmium exposure. Itai-itai predominantly affects postmenopausal women with a history of multiple childbirth. In a previous study we have examined the genotype distributions of PvuII and XbaI restriction fragment length polymorphisms of the estrogen receptor alpha (ERalpha) gene in patients with itai-itai disease and compared them with those of controls. However, no significant differences were shown between the genotype distributions of the patients and controls. In the present study, we determined the TA repeat polymorphisms of the patients and controls. The distributions of the patients were: HH 25.0%, HL 50.0%, and LL 25.0%; where HH includes two alleles with a high number of TA repeats (TA>/=16), HL includes one high number allele and one low number allele (TA
机译:Itai-itai(ouch-ouch)疾病是一种伴随骨矿物质疾病的综合症,可能与口服镉暴露有关。 Itai-itai主要影响有多胎史的绝经后妇女。在先前的研究中,我们检查了伊塔伊塔伊病患者中雌激素受体α(ERalpha)基因PvuII和XbaI限制性片段长度多态性的基因型分布,并将其与对照组进行比较。然而,在患者和对照的基因型分布之间未显示显着差异。在本研究中,我们确定了患者和对照的TA重复多态性。患者的分布为:HH 25.0%,HL 50.0%和LL 25.0%;其中HH包括两个具有高TA重复次数(TA> / = 16)的等位基因,HL包括一个高数量的等位基因和一个低数量的等位基因(TA

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