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首页> 外文期刊>Archives of Toxicology >Brain of rats intoxicated with acrylamide: observation with 4.7 tesla magnetic resonance.
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Brain of rats intoxicated with acrylamide: observation with 4.7 tesla magnetic resonance.

机译：丙烯酰胺中毒的大鼠的大脑：4.7特斯拉磁共振观察。

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摘要

When rats were injected intraperitoneally with acrylamide (50 mg/kg per day) for 8 days, all animals developed ataxia and weakness in the hindlimbs. On examining their brain with an ultrahigh-field (4.7 T) magnetic resonance (MR) spectrometer, the lateral ventricles on both sides and the third ventricle were dilated. The aqueduct and cisterns were also enlarged. The size of the cerebral cortex was quantified in three MR image slices covering the cerebrum. Compared with the images of the brain of body weight-matched controls, the cerebral cortex of rats intoxicated with acrylamide was found to be smaller in the primary motor area in all slices, and in the primary or secondary sensory area in two slices. Taken together with previous enzymatic analyses, rats intoxicated with acrylamide (50 mg/kg per day for 8 days) seem to represent an animal model of acrylamide encephalopathy not only biochemically but also structurally.
机译：当大鼠腹膜内注射丙烯酰胺（每天50 mg / kg）8天时，所有动物后肢均出现共济失调和无力。在使用超高场（4.7 T）磁共振（MR）光谱仪检查他们的大脑时，将两侧的侧脑室和第三脑室扩张了。渡槽和水箱也扩大了。在覆盖大脑的三个MR图像切片中量化大脑皮质的大小。与体重匹配对照组的大脑图像相比，发现丙烯酰胺中毒的大鼠的大脑皮层在所有切片的原发性运动区域较小，在两个切片的原发或次要感觉区域较小。与以前的酶分析一起，用丙烯酰胺中毒（每天50 mg / kg，每天8天）的大鼠似乎不仅代表了丙烯酰胺脑病的动物模型，而且还代表了其结构上的动物模型。

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