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首页> 外文期刊>Archives of Toxicology >Genotoxic effect of substituted phenoxyacetic acids.
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Genotoxic effect of substituted phenoxyacetic acids.

机译：取代苯氧乙酸的遗传毒性作用。

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The potential toxic and mutagenic action of 2,4-dichlorophenoxyacetic acid has been studied in different test systems, and the obtained results range from increased chromosomal damage to no effect at all. We reexamined the effect of this herbicide by simultaneous using three tests based on yeast, transformed hematopoietic, and mouse bone marrow cells. The results obtained demonstrated that 2,4-dichlorophenoxyacetic acid has cytotoxic and mutagenic effects. The positive response of yeast and transformed hematopoietic cells was verified in kinetics and dose-response experiments. The analysis of metaphase chromosomes indicated a statistically proved induction of breaks, deletions, and exchanges after the intraperitoneal administration of 2,4-dichlorophenoxyacetic acid in mice. The study of phenoxyacetic acid and its differently chlorinated derivatives showed that cytotoxicity and mutagenicity are induced by chlorine atoms at position 2 and/or 4 in the benzene ring. The mutagenic effect was abolished by introduction of a third chlorine atom at position 5. Thus 2,4,5-trichlorophenoxyacetic acid was found to have very weak, if any mutagenic effect; however, the herbicide preserved its toxic effect.
机译：已经在不同的测试系统中研究了2,4-二氯苯氧基乙酸的潜在毒性和诱变作用，获得的结果从增加的染色体损伤到完全没有作用。通过同时使用基于酵母，转化的造血细胞和小鼠骨髓细胞的三个测试，我们重新检查了该除草剂的作用。获得的结果证明2，4-二氯苯氧基乙酸具有细胞毒性和诱变作用。在动力学和剂量反应实验中证实了酵母和转化的造血细胞的阳性反应。对中期染色体的分析表明，在小鼠腹膜内施用2,4-二氯苯氧基乙酸后，统计证明诱导了断裂，缺失和交换。对苯氧乙酸及其不同氯化衍生物的研究表明，苯环中2和/或4位的氯原子可诱导细胞毒性和致突变性。通过在位置5引入第三个氯原子，消除了诱变作用。因此，发现2,4,5-三氯苯氧基乙酸的致突变作用非常弱;但是，除草剂保留了其毒性作用。

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