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首页> 外文期刊>Archives of Toxicology >Porphyrogenic effect of pentabromodiphenyl ether after repeated administration to rats.
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Porphyrogenic effect of pentabromodiphenyl ether after repeated administration to rats.

机译：重复给予大鼠后五溴二苯醚的成卟啉作用。

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Until recently, pentabromodiphenyl ether (PentaBDE) was most commonly used as a flame retardant. On account of the hazardous effect of PentaBDE on the environment, its use was discontinued some years ago. The toxicity of this compound has been well documented in the literature, especially with regard to the endocrine system, induction of liver microsomal enzymes, and disturbance of redox homeostasis. The aim of this study was to investigate the porphyrogenic effect of PentaBDE after its repeated administration to rats at doses of 2, 8, 40, or 200 mg/kg/day. After a 28-day exposure, a dose-dependent increase (maximum 2.5-fold) in ALA-S activity in the liver was observed. The enhanced concentration of total porphyrins in the liver (3- to 19-fold after doses of 8-200 mg/kg/day) was also found. The most pronounced changes in liver concentrations of porphyrins were shown by high carboxylated porphyrins (a 19-fold increase for octacarboxyporphyrins and a 36-fold increase for heptacarboxyporphyrins). They made over 95% of total porphyrins accumulated in the liver. The porphyrogenic effect of PentaBDE was also evidenced by the augmented urinary excretion of total porphyrins. After 28 days of exposure, the observed changes (2- to 7-fold increase) were found to be dose-dependent. Tetracarboxyporphyrins predominated in urine; their urinary concentrations were 4-12 times higher, and their daily urinary excretion is 2-9 times higher. A dose of 2 mg/kg/day was the lowest dose that caused changes in the levels of porphyrins (LOAEL). The experiment revealed the effect of PentaBDE on the heme biosynthesis and porphyrin concentrations, which indicates its porphyrogenic effect.
机译：直到最近，五溴二苯醚（PentaBDE）最常用作阻燃剂。由于五溴二苯醚对环境的有害影响，几年前已停止使用。该化合物的毒性已在文献中充分记录，尤其是在内分泌系统，肝微粒体酶的诱导以及氧化还原稳态的干扰方面。这项研究的目的是研究五溴二苯醚以2、8、40或200 mg / kg / day的剂量反复给药于大鼠后的致卟啉作用。暴露28天后，观察到肝脏中ALA-S活性呈剂量依赖性增加（最大2.5倍）。还发现肝脏中总卟啉的浓度增加（剂量为8-200 mg / kg /天后为3到19倍）。高羧化卟啉显示了卟啉肝浓度的最明显变化（八羧基卟啉增加了19倍，七羧基卟啉增加了36倍）。他们占肝脏中积累的卟啉总量的95％以上。总卟啉的尿排泄量增加也证明了五溴二苯醚的致卟啉作用。暴露28天后，发现观察到的变化（增加2至7倍）是剂量依赖性的。尿中以四羧基卟啉为主;他们的尿液浓度高出4-12倍，每天的尿液排泄量高出2-9倍。引起卟啉水平（LOAEL）变化的最低剂量为2 mg / kg /天。实验揭示了五溴二苯醚对血红素生物合成和卟啉浓度的影响，表明了其致卟啉作用。

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