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首页> 外文期刊>Archives of Toxicology >Antibiotic resistance mechanisms in M-tuberculosis: an update
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Antibiotic resistance mechanisms in M-tuberculosis: an update

机译：M结核中的抗生素耐药机制：最新进展

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Treatment of tuberculosis (TB) has been a therapeutic challenge because of not only the naturally high resistance level of Mycobacterium tuberculosis to antibiotics but also the newly acquired mutations that confer further resistance. Currently standardized regimens require patients to daily ingest up to four drugs under direct observation of a healthcare worker for a period of 6-9 months. Although they are quite effective in treating drug susceptible TB, these lengthy treatments often lead to patient non-adherence, which catalyzes for the emergence of M. tuberculosis strains that are increasingly resistant to the few available anti-TB drugs. The rapid evolution of M. tuberculosis, from mono-drug-resistant to multiple drug-resistant, extensively drug-resistant and most recently totally drug-resistant strains, is threatening to make TB once again an untreatable disease if new therapeutic options do not soon become available. Here, I discuss the molecular mechanisms by which M. tuberculosis confers its profound resistance to antibiotics. This knowledge may help in developing novel strategies for weakening drug resistance, thus enhancing the potency of available antibiotics against both drug susceptible and resistant M. tuberculosis strains.
机译：结核病（TB）的治疗一直是治疗上的挑战，这不仅是因为结核分枝杆菌对抗生素的天然高抗性水平，而且还因为新获得的突变赋予了进一步的耐药性。目前标准化的治疗方案要求患者在医护人员的直接观察下，每天摄入多达四种药物，持续6-9个月。尽管它们在治疗药物敏感的结核病方面非常有效，但这些冗长的治疗常常导致患者不依从，这催化了结核分枝杆菌菌株的出现，该菌株对几种可用的抗结核病药物越来越有抵抗力。结核分枝杆菌从单药耐药性向多种耐药性，广泛耐药性以及最近完全耐药的菌株的迅速发展，威胁说如果新的治疗方法不能很快就使结核病再次成为无法治愈的疾病变得可用。在这里，我将讨论结核分枝杆菌赋予其对抗生素的深刻抗性的分子机制。这种知识可能有助于开发新的策略来减弱耐药性，从而增强可用抗生素对药物敏感性和耐药性结核分枝杆菌菌株的效力。

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