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Influence of HBV gene heterogeneity on the failure of immunization with HBV vaccines in eastern China

机译:乙型肝炎病毒基因异质性对华东地区乙肝疫苗免疫失败的影响

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摘要

The influence of hepatitis B virus (HBV) gene heterogeneity on the failure of HBV vaccination in eastern China remains unknown. Here, we assigned 78 hepatitis B surface antigen (HBsAg)-carrier mothers to two groups: 41 mothers from whom transmission of HBV to their children was successfully prevented and 37 mothers whose children were HBsAg positive 1 year after HBV vaccination. The DNA loads in mothers of the failure group (4.17E + 07 copies/ml) were significantly higher than those in the success group (8.40E + 06 copies/ml)#
机译:在中国东部地区,乙型肝炎病毒(HBV)基因异质性对HBV疫苗接种失败的影响仍然未知。在这里,我们将78名乙型肝炎表面抗原(HBsAg)携带者的母亲分为两组:成功预防HBV向其孩子传播的41名母亲和HBV疫苗接种1年后其HBsAg阳性的母亲37名。失败组母亲的DNA负荷(4.17E + 07拷贝/毫升)显着高于成功组母亲的DNA负荷(8.40E + 06拷贝/毫升)#

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