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首页> 外文期刊>Archives of virology >Passage of low-pathogenic avian influenza (LPAI) viruses mediates rapid genetic adaptation of a wild-bird isolate in poultry.
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Passage of low-pathogenic avian influenza (LPAI) viruses mediates rapid genetic adaptation of a wild-bird isolate in poultry.

机译：低致病性禽流感（LPAI）病毒的传播介导了家禽中野生鸟类分离株的快速遗传适应。

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摘要

For a better understanding of evolution of influenza viruses, a chicken-origin and wild-bird-origin low-pathogenic avian influenza virus (LPAI) was serially passaged in chickens. Sequences of the hemagglutinin (HA) and neuraminidase (NA) genes at each passage level were compared to those of the parental virus. Multiple mutations occurring early during passage were detected, but these were maintained during passages. Interestingly, a number of the observed mutations already existed in the parental virus, as indicated by the presence of single-nucleotide polymorphisms. The greatest numbers of mutations occurred during passage of wild-bird-origin LPAI, where a 20-amino-acid deletion in the NA gene that was observed during the first passage was maintained during subsequent passages. Subsequent experiments showed that this NA deletion was already present as a minority population in the parental virus. These results showed that a selection process favoring a viral subpopulation had occurred.
机译：为了更好地了解流感病毒的进化，将鸡源性和野鸟源性低致病性禽流感病毒（LPAI）连续传给了鸡。将每个传代水平上的血凝素（HA）和神经氨酸酶（NA）基因的序列与亲本病毒的序列进行比较。检测到在传代早期发生了多个突变，但这些变异在传代期间得以维持。有趣的是，如单核苷酸多态性的存在所表明的那样，亲本病毒中已经存在许多观察到的突变。最大的突变发生在野生鸟类来源的LPAI传代期间，其中在第一次传代中观察到的NA基因中的20个氨基酸缺失在随后的传代中得以维持。随后的实验表明，这种NA缺失已作为亲本病毒中的少数群体存在。这些结果表明，已经出现了有利于病毒亚群的选择过程。

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