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首页> 外文期刊>Archives of Toxicology >Assessment of DNA damage in workers occupationally exposed to pesticide mixtures by the alkaline comet assay.
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Assessment of DNA damage in workers occupationally exposed to pesticide mixtures by the alkaline comet assay.

机译：通过碱彗星试验评估职业接触农药混合物的工人的DNA损伤。

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摘要

The potential genetic hazard of pesticides to human beings is of great concern in occupational and environmental settings because of the widespread use of these chemicals for domestic and industrial applications. Various studies have revealed a significantly elevated risk for particular tumours in humans exposed to some pesticides. Results from the biological monitoring or cytogenetic methods for the detection of health risks to pesticides have given both positive and negative results of mutagenicity. In this study DNA damage in peripheral lymphocytes of 33 pesticide-exposed workers employed in the municipality of Ankara (Turkey) for at least 1 year was examined by alkaline single-cell gel electrophoresis, the 'comet' technique. Results were compared with those from 33 controls of comparable age, sex and smoking habits, which were not occupationally exposed to pesticides. Work characteristics of the exposed workers and the use of personnel protective measures were also investigated. The DNA damage observed in lymphocytes of the workers was significantly higher than that in the controls ( P<0.001). The observed DNA damage was found to be significantly lower ( P<0.001) in workers applying some of the necessary individual safety protections during their work. Cigarette smoking was not related to increases in DNA damage; also, no significant association was found between the duration of occupational exposure to pesticides and the degree of DNA damage.
机译：在职业和环境环境中，农药对人类的潜在遗传危害备受关注，因为这些化学品已广泛用于家庭和工业用途。各种研究表明，暴露于某些农药的人患特定肿瘤的风险显着增加。通过生物监测或细胞遗传学方法检测农药对健康的危害，得出了致突变性的正面和负面结果。在这项研究中，通过碱性单细胞凝胶电泳（一种“彗星”技术）检查了安卡拉（土耳其）市33名接触农药的工人至少1年的外周淋巴细胞DNA损伤。将结果与33名年龄，性别和吸烟习惯相仿的对照组进行比较，这些对照组没有职业性接触农药。还调查了裸露工人的工作特征和人员防护措施的使用。在工人的淋巴细胞中观察到的DNA损伤明显高于对照组（P <0.001）。发现在工作期间使用某些必要的个人安全保护措施的工人观察到的DNA损伤要低得多（P <0.001）。吸烟与DNA损伤的增加无关。同样，在职业性接触农药的持续时间与DNA损伤程度之间也没有发现显着关联。

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