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首页> 外文期刊>Asian journal of animal and veterinary advances >Effects of Chemical Sympathectomy on the Level of Reproductive Hormones and Mast Cells During Mouse Early Pregnancy
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Effects of Chemical Sympathectomy on the Level of Reproductive Hormones and Mast Cells During Mouse Early Pregnancy

机译：化学交感神经切除术对小鼠早期妊娠期间生殖激素和肥大细胞水平的影响

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摘要

To test the hypothesis that the sympathetic nerve plays a crucial role on the level of 17P-estradiol, progesterone and the number and activity of mast cells in the uterus during early pregnancy and the sympathectomy mouse was established by 6-hydroxydopamine (6-OHDA) treatment. Levels of 17P-estradiol and progesterone in serum were determined by radioimmunoassay and mast cells number by histochemistry and histamine content using fluorospectrophotometry. Compared with the control, the number of embryos decreased by 64.4-69.9% in the treated groups and the level of 17P-estradiol was significantly increased at embryonic days (E3) and E9, while it was decreased at El, E5 and E7. The level of progesterone in the treated group was increased during E1-E5,with peak elevation of 2 folds at E3. The number of mast cells was highest at E3 in both the control and treated mouse. However, it was significantly increased in the treated group by 136.03, 24.54 and 177.97% at E5, E7 and E9, respectively. However, thechange in histamine content was significantly decreased 7.5-fold at E3, but increased at E7 and E9 in the treated group; it was near the limit of the detection line in the control at E7 and E9. It can be concluded that the sympathetic nerve has an effect on the synthesis and secretion of sex hormones and regulates mast cells in the uterus during early pregnancy, especially in implantation period.
机译：为了验证假说交感神经在妊娠早期子宫中17P-雌二醇，孕酮的水平以及子宫肥大细胞的数量和活性中起关键作用的假设，并通过6-羟基多巴胺（6-OHDA）建立了交感神经切除小鼠治疗。放射免疫法测定血清中17P-雌二醇和孕酮的水平，荧光分光光度法通过组织化学和组胺含量测定肥大细胞数。与对照组相比，治疗组的胚胎数量减少了64.4-69.9％，并且在胚胎天（E3）和E9时17P-雌二醇的水平显着增加，而在E1，E5和E7时则降低了。在E1-E5期间，治疗组的孕酮水平升高，在E3时的峰值升高了2倍。在对照小鼠和治疗小鼠中，肥大细胞的数量在E3最高。然而，在治疗组中，在E5，E7和E9分别显着增加136.03、24.54和177.97％。然而，治疗组中组胺含量的变化在E3时明显降低了7.5倍，而在E7和E9时增加了;它接近E7和E9控件中检测线的极限。可以得出结论，交感神经在怀孕早期，特别是在植入期，对性激素的合成和分泌有影响，并调节子宫中的肥大细胞。

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