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首页> 外文期刊>Arthritis and Rheumatism >Comparison of Children With Onset of Juvenile Dermatomyositis Symptoms Before or After Their Fifth Birthday in a UK and Ireland Juvenile Dermatomyositis Cohort Study
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Comparison of Children With Onset of Juvenile Dermatomyositis Symptoms Before or After Their Fifth Birthday in a UK and Ireland Juvenile Dermatomyositis Cohort Study

机译：在英国和爱尔兰的青少年皮肌炎队列研究中比较五岁之前或之后出现青少年皮肌炎症状的儿童

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Objective. To compare 2 groups of children with juvenile dermatomyositis (DM), those with onset of symptoms before their fifth birthday versus those whose disease begins either on or after their fifth birthday, and to assess whether age at onset is associated with differences in disease presentation, treatments received, or outcomes 2 years after diagnosis. Methods. Data were analyzed on children recruited to a UK juvenile DM cohort study with a diagnosis of probable or definite juvenile DM and less than 12 months between diagnosis and recruitment.Results. Fifty-five (35%) of 157 children had onset of symptoms before their fifth birthday. At diagnosis, cutaneous ulceration was found in 32.% of the younger group versus 11.8% of the older group (P = 0.003). Facial or body swelling was reported more often in me younger group, whereas headaches, alopecia, and Raynaud's phenomenon were all more frequently reported in the older group. At followup 2 years later, there were no important differences in outcomes between the groups. More than 90% of patients in both groups receivedboth methotrexate and steroids. Twenty-three percent of both groups remained on steroids 2 years after diagnosis.Conclusion. Our study showed that children with juvenile DM with disease onset at age <5 years are more likely to present with ulcerative skin disease and edema. There were no clinically significant differences in outcomes between the 2 groups.
机译：目的。为了比较两组患青少年皮肌炎（DM）的儿童，即在五岁生日之前出现症状的儿童与在五岁生日之后开始疾病的儿童，并评估发病年龄是否与疾病表现的差异相关，诊断后2年内接受治疗或有结果。方法。对入选英国DM队列研究的儿童的数据进行了分析，这些儿童被诊断出患有DM或确诊为DM，并且从诊断到募集之间的时间少于12个月。 157名儿童中有55名（35％）在五岁生日之前出现症状。诊断时，年轻组的皮肤溃疡发生率为32.％，老年组为11.8％（P = 0.003）。在我的年轻组中，面部或身体肿胀的报道较多，而在较老的组中，头痛，脱发和雷诺现象的发生率更高。两年后的随访中，两组之间的结局无重大差异。两组中90％以上的患者均接受甲氨蝶呤和类固醇激素治疗。在诊断后2年，两组中有23％的人仍使用类固醇。我们的研究表明，年龄小于5岁的青少年DM儿童更容易出现溃疡性皮肤病和水肿。两组之间结局在临床上无显着差异。

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