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首页> 外文期刊>Arthritis care & research >Association of discoid lupus erythematosus with clinical manifestations and damage accrual in a multiethnic lupus cohort.
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Association of discoid lupus erythematosus with clinical manifestations and damage accrual in a multiethnic lupus cohort.

机译：盘状红斑狼疮与多种族狼疮队列的临床表现和应计损伤的关联。

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摘要

To determine the clinical manifestations and disease damage associated with discoid rash in a large multiethnic systemic lupus erythematosus (SLE) cohort.SLE patients (per American College of Rheumatology [ACR] criteria) ages ≥16 years with a disease duration of ≤10 years at enrollment and defined ethnicity (African American, Hispanic, or white) from a longitudinal cohort were studied. Socioeconomic-demographic features, clinical manifestations, and disease damage (per the Systemic Lupus International Collaborating Clinics/ACR Damage Index) were determined. The association of discoid lupus erythematosus (DLE) with clinical manifestations and disease damage was examined using multivariable logistic regression.A total of 2,228 SLE patients were studied. The mean ± SD age at diagnosis was 34.3 ± 12.8 years and the mean ± SD disease duration was 7.9 ± 6.0 years; 91.8% were women. DLE was observed in 393 patients with SLE (17.6%). In the multivariable analysis, patients with DLE were more likely to be smokers and of African American ethnicity and to have malar rash, photosensitivity, oral ulcers, leukopenia, and vasculitis. DLE patients were less likely to be of Hispanic (from Texas) ethnicity and to have arthritis, end-stage renal disease, and antinuclear, anti-double-stranded DNA, and antiphospholipid antibodies. Patients with DLE had more damage accrual, particularly chronic seizures, scarring alopecia, scarring of the skin, and skin ulcers.In this cohort of SLE patients, DLE was associated with several clinical features, including serious manifestations such as vasculitis and chronic seizures.
机译：确定大型多种族系统性红斑狼疮（SLE）队列中与盘状皮疹相关的临床表现和疾病损害。SLE患者（根据美国风湿病学会[ACR]标准）年龄≥16岁，疾病持续时间≤10年，研究了纵向队列的招生和特定种族（非裔，西班牙裔或白人）。确定了社会经济人口统计学特征，临床表现和疾病损害（根据系统性狼疮国际合作诊所/ ACR损害指数）。使用多因素Logistic回归分析了盘状红斑狼疮（DLE）与临床表现和疾病损害之间的关系。共研究了2,228例SLE患者。诊断时的平均±SD年龄为34.3±12.8岁，疾病的平均±SD病程为7.9±6.0年。 91.8％是妇女。在393例SLE患者中观察到DLE（17.6％）。在多变量分析中，DLE患者更可能是吸烟者和非裔美国人，并且患有黄斑疹，光敏性，口腔溃疡，白细胞减少症和血管炎。 DLE患者不太可能是西班牙裔（得克萨斯州），患有关节炎，晚期肾病，抗核，抗双链DNA和抗磷脂抗体。 DLE患者的损伤增加较多，特别是慢性癫痫发作，疤痕性脱发，皮肤疤痕和皮肤溃疡。在这一系列SLE患者中，DLE具有多种临床特征，包括血管炎和慢性癫痫发作等严重表现。

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