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首页> 外文期刊>Arthritis care & research >Macrophage activation and coronary atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis.
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Macrophage activation and coronary atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis.

机译：系统性红斑狼疮和类风湿关节炎的巨噬细胞活化和冠状动脉粥样硬化。

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OBJECTIVE: Activation of macrophages may contribute to increased atherosclerosis and coronary artery disease in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Neopterin, a pteridine derivative, is a novel marker of monocyte and macrophage activation that is associated with atherosclerosis and cardiovascular risk in the general population. We examined the hypothesis that macrophage activation is associated with accelerated atherosclerosis in SLE and RA. METHODS: We compared serum neopterin concentrations, adjusted for age, race, sex, and serum creatinine concentration, in patients with SLE (n=148) or RA (n=166) and control subjects (n=177). In patients with SLE or RA, serum neopterin concentrations were then tested for association (adjusted for age, race, sex, serum creatinine, and medication use) with measures of disease activity or damage, inflammatory markers and mediators, and coronary artery calcium measured by electron beam computed tomography. RESULTS: Neopterin concentrations were significantly higher in patients with SLE (median 8.0, interquartile range [IQR] 6.5-9.8 nmoles/liter) and RA (median 6.7, IQR 5.3-8.9 nmoles/liter) than controls (median 5.7, IQR 4.8-7.1 nmoles/liter), and were higher in SLE patients than in RA patients (all P<0.001). In SLE, neopterin was significantly correlated with higher erythrocyte sedimentation rate (ESR; P=0.001), tumor necrosis factor alpha (P<0.001), monocyte chemoattractant protein 1 (P=0.005), and homocysteine concentrations (P=0.01), but in RA, it was only associated with ESR (P=0.01). Neopterin was not associated with coronary calcium in either SLE (P=0.65) or RA (P=0.21). CONCLUSION: Macrophage activation, reflected by increased serum neopterin concentrations, was increased in both SLE and RA. Neopterin was more robustly associated with atherogenic mediators of inflammation and homocysteine in SLE than in RA, but was not associated with coronary atherosclerosis in either disease.
机译：目的：巨噬细胞的活化可能导致系统性红斑狼疮（SLE）和类风湿关节炎（RA）的动脉粥样硬化和冠状动脉疾病增加。新蝶呤是蝶啶的衍生物，是单核细胞和巨噬细胞活化的新标志物，与一般人群的动脉粥样硬化和心血管风险有关。我们检查了这一假设，即巨噬细胞激活与SLE和RA中的动脉粥样硬化加速有关。方法：我们比较了SLE（n = 148）或RA（n = 166）和对照组（n = 177）的患者的血清新蝶呤浓度（经年龄，种族，性别和血清肌酐浓度校正）。然后，对患有SLE或RA的患者，测试其血清新蝶呤的浓度（根据年龄，种族，性别，血清肌酐和药物使用情况进行调整）与疾病活动或损害，炎性标志物和介体的关系以及通过电子束计算机断层扫描。结果：SLE（中位数8.0，四分位间距[IQR] 6.5-9.8 nmoles / l）和RA（中位数6.7，IQR 5.3-8.9 nmoles / l）的新蝶呤浓度显着高于对照组（中位数5.7，IQR 4.8- SLE患者的血脂水平为7.1毫摩尔/升，高于RA患者（所有P <0.001）。在SLE中，新蝶呤与较高的红细胞沉降率（ESR; P = 0.001），肿瘤坏死因子α（P <0.001），单核细胞趋化蛋白1（P = 0.005）和高半胱氨酸浓度（P = 0.01）显着相关，但是在RA中，它仅与ESR相关（P = 0.01）。新蝶呤与SLE（P = 0.65）或RA（P = 0.21）的冠状动脉钙化均无关。结论：SLE和RA中血清新蝶呤浓度升高反映出巨噬细胞活化。与RA相比，新蝶呤与SLE中炎症和高半胱氨酸的动脉粥样硬化介质更紧密相关，但在两种疾病中均与冠状动脉粥样硬化无关。

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