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首页> 外文期刊>Arthritis care & research >Rates of Change and Sensitivity to Change in Cartilage Morphology in Healthy Knees and in Knees With Mild, Moderate, and End-Stage Radiographic Osteoarthritis: Results From 831 Participants From the Osteoarthritis Initiative
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Rates of Change and Sensitivity to Change in Cartilage Morphology in Healthy Knees and in Knees With Mild, Moderate, and End-Stage Radiographic Osteoarthritis: Results From 831 Participants From the Osteoarthritis Initiative

机译：健康膝关节和轻度，中度和终末期影像学骨关节炎的膝关节软骨形态变化的变化率和敏感性变化：骨关节炎倡议的831名参与者的结果

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摘要

To study the longitudinal rate of (and sensitivity to) change of knee cartilage thickness across defined stages of radiographic osteoarthritis (OA), specifically healthy knees and knees with end-stage radiographic OA. Methods. One knee of 831 Osteoarthritis Initiative participants was examined: 112 healthy knees, without radiographic OA or risk factors for knee OA, and 719 radiographic OA knees (310 calculated Kellgren/Lawrence [K/L] grade 2, 300 calculated K/L grade 3, and 109 calculated K/L grade 4). Subregional change in thickness was assessed after segmentation of weight-bearing femorotibial cartilage at baseline and 1 year from coronal magnetic resonance imaging (MRI). Regional and ordered values (OVs) of change were compared by baseline radiographic OA status.Results. Healthy knees displayed small changes in plates and subregions (+-0.7%; standardized response mean [SRM] +-0.15), with OVs being symmetrically distributed close to zero. In calculated K/L grade 2 knees, changes in cartilage thickness were small (<1%; minimal SRM -0.22) and not significantly different from healthy knees. Knees with calculated K/L grade 3 showed substantial loss of cartilage thickness (up to -2.5%; minimal SRM -0.35), with OVl changes being significantly [P < 0.05) greater than those in healthy knees. Calculated K/L grade 4 knees displayed the largest rate of loss across radiographic OA grades (up to -3.9%; minimal SRM -0.51), with OVl changes also significantly [P < 0.05) greater than in healthy knees. Conclusion. MRI-based cartilage thickness showed high rates of loss in knees with moderate and end-stage radiographic OA, and small rates (indistinguishable from healthy knees) in mild radiographic OA. From the perspective of sensitivity to change, end-stage radiographic OA knees need not be excluded from longitudinal studies using MRI cartilage morphology as an end point.
机译：研究在确定的放射影像性骨关节炎（OA）特定阶段，特别是健康的膝盖和末期放射影像学OA的膝盖中，膝关节软骨厚度变化的纵向速率（及其敏感性）。方法。检查了831名骨关节炎倡议参与者的一只膝盖：112根健康的膝盖，没有X线片OA或膝OA的危险因素，以及719片X线片OA膝盖（310计算为Kellgren / Lawrence [K / L] 2级，300计算为K / L 3级） ，并计算出109级的K / L 4级）。在基线和冠状磁共振成像（MRI）1年后对负重股骨软骨进行分割后，评估了亚区域厚度的变化。通过基线影像学OA状态对变化的区域值和有序值（OVs）进行了比较。健康的膝盖在板块和子区域中显示微小变化（+ -0.7％;标准响应平均值[SRM] + -0.15），OVs对称分布接近零。在计算得出的K / L 2级膝盖中，软骨厚度的变化很小（<1％;最小SRM -0.22），与健康膝盖没有显着差异。计算得出的K / L等级为3的膝关节软骨厚度显着下降（最高-2.5％;最小SRM -0.35），OV1的变化明显大于健康膝关节的[P <0.05）。计算得出的K / L 4级膝关节在X线摄片OA级中表现出最大的丢失率（高达-3.9％;最小SRM -0.51），OVl的变化也明显大于健康膝盖（P <0.05）。结论。基于MRI的软骨厚度显示，中度X线和终末期X线OA膝关节损失率高，轻度X线OA膝关节损失率低（与健康膝盖无区别）。从对变化的敏感性的角度来看，使用MRI软骨形态学作为终点的纵向研究无需排除放射线照相OA膝关节的终末期。

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