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Exercise Training in Juvenile Dermatomyositis

机译：青少年皮肌炎的运动训练

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Objective. To investigate the effects of a supervised exercise training program on health parameters, physical capacity, and health-related quality of life in patients with mild and chronic juvenile dermatomyositis (DM). Methods. This was a prospective longitudinal study following 10 children with mild and chronic juvenile DM (disease duration >1 year). The exercise program consisted of twice-a-week aerobic and resistance training. At baseline and after the 12-week intervention, we assessed muscle strength and function, aerobic conditioning, body composition, juvenile DM scores, and health-related quality of life.Results. Child self-report and parent proxy-report Pediatric Quality of Life Inventory scores were improved after the intervention (-40.3%; P = 0.001 and -48.2%; P = 0.049, respectively). Importantly, after exercise, the Disease Activity Score was reduced (-26.9%; P = 0.026) and the Childhood Muscle Assessment Scale was improved (+2.5%; P = 0.009), whereas the Manual Muscle Test presented a trend toward statistical significance (+2.2%; P = 0.081). The peak oxygen consumption and time-to-exhaustion were increased by 13.3% (P = 0.001) and 18.2% (P = 0.003), respectively, whereas resting heart rate was decreased by 14.7% (P = 0.006), indicating important cardiovascular adaptations to the exercise program. Upper and lower extremity muscle strength and muscle function were also significantly improved after the exercise training (P < 0.05). Both the whole-body and the lumbar spine bone mineral apparent density were significantly increased after training (1.44%; P = 0.044 and 2.85%; P = 0.008, respectively).Conclusion. We showed for the first time that a 12-week supervised exercise program is safe and can improve muscle strength and function, aerobic conditioning, bone mass, disease activity, and health-related quality of life in patients with active and nonactive mild and chronic juvenile DM with near normal physical function and quality of life.
机译：目的。调查有监督的运动训练计划对轻度和慢性青少年皮肌炎（DM）患者健康参数，身体能力和与健康相关的生活质量的影响。方法。这是一项前瞻性纵向研究，研究对象为10例轻度和慢性青少年DM（疾病持续时间> 1年）的儿童。锻炼计划包括每周两次有氧和阻力训练。在基线和12周的干预后，我们评估了肌肉的力量和功能，有氧条件，身体成分，青少年DM得分以及与健康相关的生活质量。干预后，儿童的自我报告和父母的代理人报告的小儿生活质量量表得分得到改善（分别为-40.3％; P = 0.001和-48.2％; P = 0.049）。重要的是，运动后，疾病活动评分降低了（-26.9％; P = 0.026），儿童肌肉评估量表得到了改进（+ 2.5％; P = 0.009），而手动肌肉测试则呈现了统计学上的显着趋势（ + 2.2％; P = 0.081）。峰值耗氧量和耗竭时间分别增加了13.3％（P = 0.001）和18.2％（P = 0.003），而静息心率降低了14.7％（P = 0.006），表明重要的心血管适应锻炼程序。运动训练后，上肢和下肢的肌肉力量和肌肉功能也明显改善（P <0.05）。训练后全身和腰椎骨矿物质表观密度均显着增加（分别为1.44％; P = 0.044和2.85％; P = 0.008）。我们首次展示了为期12周的有监督运动计划是安全的，并且可以改善活跃和不活跃的轻度和慢性少年患者的肌肉力量和功能，有氧条件，骨骼质量，疾病活动以及与健康相关的生活质量DM具有接近正常的身体机能和生活质量。

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