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首页> 外文期刊>Artificial cells, blood substitutes, and biotechnology >Hemoglobin-based oxygen carrier (HBOC-201) and escalating doses of recombinant factor VIIa (rFVIIa) as a novel pre-hospital resuscitation fluid in a swine model of severe uncontrolled hemorrhage.
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Hemoglobin-based oxygen carrier (HBOC-201) and escalating doses of recombinant factor VIIa (rFVIIa) as a novel pre-hospital resuscitation fluid in a swine model of severe uncontrolled hemorrhage.

机译：基于血红蛋白的氧气载体（HBOC-201）和递增剂量的重组VIIa因子（rFVIIa），作为严重失控出血猪模型中新型的院前复苏液。

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摘要

Exsanguinating hemorrhage and unavailability of blood are major problems in pre-hospital trauma care. We investigated if combining rFVIIa with HBOC-201 reduces blood loss and improves physiologic parameters compared to HBOC alone. Swine underwent liver injury and were resuscitated with HBOC-201 alone or HBOC+90, 180 or 360 mug/kg rFVIIa before hospital arrival at 240 min; animals survived to 72 hours. Blood loss was reduced; MAP, CI, transcutaneous oxygen saturation, and 72-hour survival improved in the 90 and 180 mug/kg rFVIIa groups. Lactate was cleared faster in the HBOC+rFVIIa 90 mug/kg group. Verification in a large, well-powered study is indicated.
机译：在院前创伤护理中，失血过多和血液供应不足是主要问题。我们研究了与单独的HBOC相比，rFVIIa与HBOC-201的结合是否可减少失血并改善生理参数。猪遭受肝损伤，并在住院240分钟前用单独的HBOC-201或HBOC + 90、180或360杯/ kg rFVIIa复苏。动物存活至72小时。失血减少;在90和180马克杯/千克rFVIIa组中，MAP，CI，经皮血氧饱和度和72小时生存率得到改善。 HBOC + rFVIIa 90杯/千克组的乳酸清除速度更快。需要在一个功能强大的大型研究中进行验证。

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