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首页> 外文期刊>Artificial cells, blood substitutes, and biotechnology >Hypoxia due to shunts in pig lung treated with O2 and fluorocarbon-derived intravascular microbubbles
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Hypoxia due to shunts in pig lung treated with O2 and fluorocarbon-derived intravascular microbubbles

机译：O2和碳氟化合物衍生的血管内微气泡治疗猪肺分流引起的缺氧

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Rationale: Earlier work has shown that experimental conditions calling for improved tissue oxygenation could be assisted by i.v. infusion of a dodecafluoropentane emulsion (DDFPe) forming oxygen-transporting microbubbles. Objectives: The present work investigated the effect of DDFPe on hypoxia due to experimental shunts in the pig lung. Methods: Nineteen O2 breathing, anesthetized pigs had glass beads administered into the trachea so as to significantly depress arterial oxygen tension (PaO2). PaO2 was recorded for up to 12 hrs while 0.1 ml/kg DDFPe was administered 13 times. Main Results: The animals were divided into two groups based on arterial oxygen saturation (SaO2) after shunt induction, combined with oxygen breathing: the "SaO2 90% group" (n6) and the "SaO2 90% group" (n13). In the "SaO2 90% group," the PaO2 increased stepwise with each infusion from 56.6±2.9 to 88.6±14.6 mmHG (P≤0.001); improvements lasted about 2 hrs after each infusion. Mixed venous oxygenation also increased with the infusions, e.g. (1st infusion) from a PvO2 of 41.4±2.3 to 49.9±4.2 mmHg (P≤0.05) and SvO2 58.0±2.9% (P≤0.01), the venous changes supporting arterial oxygenation. At the same time, arterial CO2 levels fell. Arterial O2 and CO2 levels were paralleled by similar changes in muscle tissue. Pulmonary arterial pressures did not indicate any pulmonary embolization by bubbles. Toxic effects of the treatment were not observed. Conclusion: These results suggest that, on condition of successful toxicity testing, intravascular administration of a DDFPe and oxygen breathing may be beneficial in severe right-to-left shunting in humans.
机译：基本原理：较早的工作表明，通过静脉内注射可以改善组织氧合的实验条件。注入十二氟戊烷乳液（DDFPe）形成输氧微气泡。目的：本研究调查了DDFPe对猪肺中实验性分流引起的缺氧的影响。方法：十九只O2呼吸的麻醉猪在气管内注入玻璃珠，以显着降低动脉血氧分压（PaO2）。 PaO2记录长达12小时，而0.1 ml / kg DDFPe施用了13次。主要结果：在分流诱导后，根据动脉血氧饱和度（SaO2）将动物分为两组，并结合氧气呼吸：“ SaO2> 90％组”（n6）和“ SaO2 <90％组”（n13） 。在“ SaO2 <90％组”中，每次注入的PaO2从56.6±2.9 mmHG逐步增加到88.6±14.6 mmHG（P≤0.001）;每次输注后改善持续约2小时。混合静脉氧合也随着输注而增加，例如（第一次输注）PvO2为41.4±2.3至49.9±4.2 mmHg（P≤0.05）和SvO2为58.0±2.9％（P≤0.01），静脉变化支持动脉氧合。同时，动脉二氧化碳水平下降。动脉中的O2和CO2水平与肌肉组织中的类似变化平行。肺动脉压未显示任何肺泡栓塞。没有观察到该治疗的毒性作用。结论：这些结果表明，在成功进行毒性测试的条件下，对DDFPe进行血管内给药和进行氧气呼吸可能对人体从右到左的严重分流有好处。

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