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首页> 外文期刊>Artificial cells, blood substitutes, and biotechnology >Magnetic resonance spectroscopy for evaluation of liposome-encapsulated hemoglobin as a resuscitation fluid
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Magnetic resonance spectroscopy for evaluation of liposome-encapsulated hemoglobin as a resuscitation fluid

机译：磁共振波谱法评价脂质体包裹的血红蛋白作为复苏液

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Liposome-encapsulated hemoglobin (LEH) based on a novel, synthetic, non-phospholipid was developed, and evaluated for cerebral energy metabolism in a 40% hemorrhage rat model. The markers of tissue energetics were monitored by 1H- and 31P-magnetic resonance spectroscopy (MRS). After hemorrhage, 1H-MRS showed an increase in the levels of lactate and pyruvate. These markers returned to baseline values following LEH resuscitation. Both LEH and saline were able to exert a neuron-protective effect as indicated by the recovery of N-acetylaspartate. 31P MRS showed a fall in phosphocreatine after hemorrhage, which upon LEH or saline resuscitation returned to the baseline values. Similarly, inorganic phosphate increased after bleeding, but returned to normal after resuscitation. LEH resuscitation also recovered β-ATP levels, but saline resuscitation provided only a modest recovery. The results indicate the utility of MRS to monitor cerebral metabolism in hemorrhage/resuscitation. The data is also supportive of the new LEH formulation as an oxygen carrier.
机译：基于新型合成的非磷脂脂质体包裹的血红蛋白（LEH）已开发出来，并在40％出血的大鼠模型中评估了脑能量代谢。通过1H和31P磁共振波谱（MRS）监测组织能量学的标志物。出血后，1H-MRS显示乳酸和丙酮酸水平升高。 LEH复苏后，这些标志物恢复到基线值。 LEH和盐水都能够发挥神经元保护作用，如N-乙酰天冬氨酸的回收所表明的。 31P MRS出血后磷酸肌酸下降，LEH或盐水复苏后恢复到基线值。同样，出血后无机磷酸盐增加，但复苏后恢复正常。 LEH复苏也恢复了β-ATP水平，但是盐水复苏仅提供了适度的恢复。结果表明，MRS可用于监测出血/复苏中的脑代谢。数据也支持新的LEH配方作为氧气载体。

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