Early treatment of transient focal cerebral ischemia with bovine PEGylated carboxy hemoglobin transfusion

KlausJ.A.; KiblerK.K.; AbuchowskiA.; KoehlerR.C.

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Early treatment of transient focal cerebral ischemia with bovine PEGylated carboxy hemoglobin transfusion

机译：牛PEG化羧基血红蛋白输注治疗短暂性局灶性脑缺血

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The effect of transfusion of PEGylated hemoglobin (PEG-Hb) was evaluated in anesthetized rats subjected to 2 hours of focal cerebral ischemia and 1 day of reperfusion. PEG-Hb was stored in the carboxy state (PEG-COHb) to reduce autooxidation and increase the shelf life. Transfusion of 10 ml/kg of PEG-COHb at 20 minutes of ischemia did not alter arterial blood pressure or increase red cell flux in the ischemic core. Plasma hemoglobin increased to only 0.6 g/dL, yet infarct volume was markedly decreased and neurological deficits were improved. We conclude that early topload transfusion of PEG-COHb protects the brain from ischemic stroke.

机译：在经历2小时局灶性脑缺血和1天再灌注的麻醉大鼠中评估了PEG化血红蛋白（PEG-Hb）的输血效果。 PEG-Hb以羧基状态（PEG-COHb）存储，以减少自氧化作用并延长保质期。在缺血20分钟时输注10 ml / kg的PEG-COHb不会改变动脉血压或增加缺血核心的红细胞通量。血浆血红蛋白仅增至0.6 g / dL，但梗塞体积明显减少，神经功能缺损得到改善。我们得出的结论是，早期的PEG-COHb最高负荷输注可保护大脑免受缺血性中风的侵害。

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《Artificial cells, blood substitutes, and biotechnology》 |2010年第5期|共7页
作者
KlausJ.A.; KiblerK.K.; AbuchowskiA.; KoehlerR.C.;
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正文语种 eng
中图分类生物医学工程;
关键词
Blood substitute; Carbon monoxide; Focal cerebral ischemia; PEGylated hemoglobin; Stroke;

机译：血液替代品;一氧化碳;局部脑缺血;聚乙二醇化血红蛋白;中风;

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1. Early treatment of transient focal cerebral ischemia with bovine PEGylated carboxy hemoglobin transfusion [J] . KlausJ.A., KiblerK.K., AbuchowskiA., Artificial cells, blood substitutes, and biotechnology . 2010,第5期

机译：牛PEG化羧基血红蛋白输注治疗短暂性局灶性脑缺血
2. Decreased damage from transient focal cerebral ischemia by transfusion of zero-link hemoglobin polymers in mouse. [J] . Mito T, Nemoto M, Kwansa H, Stroke: A Journal of Cerebral Circulation . 2009,第1期

机译：通过在小鼠中输注零链接血红蛋白聚合物，减少了短暂性局灶性脑缺血的损害。
3. SANGUINATE? (PEGylated Carboxyhemoglobin Bovine) Improves Cerebral Blood Flow to Vulnerable Brain Regions at Risk of Delayed Cerebral Ischemia After Subarachnoid Hemorrhage [J] . Rajat Dhar, Hemant Misra, Michael N. Diringer Neurocritical care . 2017,第3期

机译：划伤？（Pegymated Carboxyhemoglobin牛）在蛛网膜下腔出血后有脑缺血的风险改善脑血流量。
4. Study of neurovascular coupling functions for transient focal cerebral ischemia in rats using electrocorticography functional photoacoustic microscopy (ECoG-fPAM) [C] . Liao, Lun-De, Li, Meng-Lin, Lai, Hsin-Yi, Annual Conference of Japanese Society for Medical and Biological Engineering;Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2013

机译：使用脑电图功能光声显微镜（ECoG-fPAM）研究大鼠短暂性局灶性脑缺血的神经血管偶联功能
5. Pulsed Transcranial Ultrasound Stimulation and its Applications in Treatment of Focal Cerebral Ischemia and Depression [D] . Li, Hangdao. 2018

机译：脉冲经颅超声刺激及其在局灶性脑缺血和抑郁症中的应用
6. Early Treatment of Transient Focal Cerebral Ischemia with Bovine PEGylated Carboxy Hemoglobin Transfusion [O] . Judith A. Klaus, Kathleen K. Kibler, Abraham Abuchowski, -1

机译：早期治疗尿液聚乙酰胺羧基血红蛋白输血的瞬时焦脑缺血
7. Early Treatment of Transient Focal Cerebral Ischemia with Bovine PEGylated Carboxy Hemoglobin Transfusion [O] . Judith A. Klaus, Kathleen K. Kibler, Abraham Abuchowski, 2015

机译：牛聚乙二醇化羧化血红蛋白输注治疗短暂性局灶性脑缺血的早期治疗
8. Carboxy Hemoglobin Formation Due to Transient Exposure to High Level CarbonMonoxide: Experimental Results and an Explanatory Model [R] . Hazucha, M. J., Smith, M. V., Benignus, V. A., 1994

机译：由于瞬时暴露于高水平的碳氧化物而形成羧基血红蛋白：实验结果和解释模型

Early treatment of transient focal cerebral ischemia with bovine PEGylated carboxy hemoglobin transfusion

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