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首页> 外文期刊>Artificial cells, blood substitutes, and biotechnology >Pretreatment before ischemia induction with polymerized human placenta hemoglobin (PolyPHb) attenuates ischemia/reperfusion injury-induced myocardial apoptosis.
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Pretreatment before ischemia induction with polymerized human placenta hemoglobin (PolyPHb) attenuates ischemia/reperfusion injury-induced myocardial apoptosis.

机译：聚合诱导的人胎盘血红蛋白（PolyPHb）在缺血诱导前进行预处理可减轻缺血/再灌注损伤诱导的心肌细胞凋亡。

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摘要

This study was designed to investigate the influence of polymerized human placenta hemoglobin (PolyPHb) pretreatment on ischemia/reperfusion (I/R) injury-induced myocardial apoptosis. Isolated Sprague-Dawley rat hearts were perfused by Langendorff model. After basal perfusion, hearts were arrested by St.Thomas' solution (STS) with (Pre-HBOC group) or without PolyPHb (STS group), then subjected to I/R injury. Our results showed that PolyPHb pretreatment greatly reduced the TUNEL-positive myocardial cells and decreased the caspase-3 activity and cleavage, which was further confirmed by the linear regression analysis. Therefore, PolyPHb pretreatment was beneficial to attenuation of myocardial apoptosis and provided protection to the heart against I/R injury.
机译：这项研究旨在调查聚合的人胎盘血红蛋白（PolyPHb）预处理对缺血/再灌注（I / R）损伤诱导的心肌细胞凋亡的影响。用Langendorff模型灌注离体的Sprague-Dawley大鼠心脏。基础灌注后，在有（Pre-HBOC组）或无PolyPHb（STS组）的St.Thomas溶液（STS）阻滞心脏，然后对其进行I / R损伤。我们的结果表明，PolyPHb预处理可大大减少TUNEL阳性心肌细胞，并降低caspase-3活性和裂解，这通过线性回归分析进一步得到证实。因此，PolyPHb预处理有益于减轻心肌细胞凋亡，并为心脏提供抗I / R损伤的保护。

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