Oxidative damage shifts from lipid peroxidation to thiol arylation by catechol-containing antioxidants.

Boots A; Haenen G; den Hartog G; Bast A

首页> 外文期刊>Biochimica et biophysica acta: international journal of biochemistry and biophysics >Oxidative damage shifts from lipid peroxidation to thiol arylation by catechol-containing antioxidants.

【24h】

Oxidative damage shifts from lipid peroxidation to thiol arylation by catechol-containing antioxidants.

机译：氧化损伤由含邻苯二酚的抗氧化剂从脂质过氧化转变为硫醇芳基化。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Catechol-containing antioxidants are able to protect against lipid peroxidation by nonenzymatic scavenging of free radicals with their catechol moiety. During their antioxidant activity, catechol oxidation products such as semiquinone radicals and quinones are formed. These oxidation products of 4-methylcatechol inactivate the GSH-dependent protection against lipid peroxidation and the calcium sequestration in liver microsomes. This effect is probably due to arylation by oxidation products of 4-methylcatechol of free thiol groups of the enzymes responsible for the GSH-dependent protection and calcium sequestration, i.e. the free radical reductase and calcium ATPase. It is concluded that a catechol-containing antioxidant might shift radical damage from lipid peroxidation to sulfhydryl arylation.

机译：含儿茶酚的抗氧化剂能够通过非酶清除儿茶酚部分的自由基来防止脂质过氧化。在其抗氧化活性期间，会形成邻苯二酚氧化产物，例如半醌自由基和醌。这些4-甲基邻苯二酚的氧化产物会失活GSH依赖性保护作用，以抵抗脂质过氧化作用和肝微粒体中的钙螯合。该作用可能是由于负责GSH依赖性保护和钙螯合的酶（即自由基还原酶和ATP酶）的游离巯基的4-甲基邻苯二酚的氧化产物芳基化。结论是含邻苯二酚的抗氧化剂可能将自由基损伤从脂质过氧化转变为巯基芳基化。

著录项

来源
《Biochimica et biophysica acta: international journal of biochemistry and biophysics》 |2002年第3期|共1页
作者
Boots A; Haenen G; den Hartog G; Bast A;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
catechol; peroxidation; Lipids; Antioxidants; protect; 脂类; 抗氧化药;

机译：catechol;peroxidation;Lipids;Antioxidants;protect;脂类;抗氧化药;

相似文献

外文文献
中文文献
专利

1. Oxidative damage shifts from lipid peroxidation to thiol arylation by catechol-containing antioxidants. [J] . Boots A, Haenen G, den Hartog G, Biochimica et biophysica acta: international journal of biochemistry and biophysics . 2002,第3期

机译：氧化损伤由含邻苯二酚的抗氧化剂从脂质过氧化转变为硫醇芳基化。
2. Oxidative damage to sarcoplasmic reticulum Ca~(2+)-pump induced by Fe~(2+)/H_2O_2/ascorbate is not mediated by lipid peroxidation or thiol oxidation and leads to protein fragmentation [J] . Roger F. Castilho, Paulo C. Carvalho-Alves, Anibal E. Vercesi, Molecular and Cellular Biochemistry: An International Journal for Chemical Biology . 1996,第2期

机译：Fe〜（2 +）/ H_2O_2 /抗坏血酸对肌浆网Ca〜（2+）泵的氧化损伤不是由脂质过氧化或硫醇氧化介导的，而是导致蛋白质断裂
3. Lipid peroxidation and generation of hydrogen peroxide in frozen-thawed ram semen cryopreserved in extenders with antioxidants. [J] . Maia M. da S., Bicudo S. D., Sicherle C. C., Animal Reproduction Science . 2010,第1a2期

机译：冷冻解冻的公羊精液中的脂质过氧化和过氧化氢的生成在抗氧化剂增量剂中冷冻保存。
4. The Effect of Red Dragon Fruit Extract (Hylocereus Polyrhizus) on Membrane Lipid Peroxidation and Liver Tissue Damage Triggered by Hyperlipidemia in White Rats (Rattus Norvegicus) [C] . Maria Selvester Thadeus, Cut Fauziah, Fajriati Zulfa, International Conference on Health Sciences . 2019

机译：红龙果提取物（Hylocereus Polyrhizus）对白老鼠高脂血症（Rattus Norvegicus）触发膜脂过氧化和肝组织损伤的影响
5. Biological assessment and methods to evaluate lipid peroxidation when feeding thermally-oxidized lipids to young pigs [D] . Liu, Pai 2012

机译：向仔猪饲喂热氧化脂质时的生物学评估和评估脂质过氧化的方法
6. Possible involvement of membrane lipids peroxidation and oxidation of catalytically essential thiols of the cerebral transmembrane sodium pump as component mechanisms of iron-mediated oxidative stress-linked dysfunction of the pumps activity [O] . T.I. Omotayo, G.S. Akinyemi, P.A. Omololu, 2015

机译：膜脂质过氧化作用和脑跨膜钠泵催化必需硫醇的氧化可能参与铁泵介导的氧化应激相关功能障碍
7. Possible involvement of membrane lipids peroxidation and oxidation of catalytically essential thiols of the cerebral transmembrane sodium pump as component mechanisms of iron-mediated oxidative stress-linked dysfunction of the pump's activity [O] . T.I. Omotayo, G.S. Akinyemi, P.A. Omololu, 2015

机译：可能涉及膜脂质过氧化和脑转移钠泵催化必需硫醇的氧化作为铁介导的氧化应激相关的泵活动功能障碍的组成机制
8. Wood Smoke Particles Generate Free Radicals and Cause Lipid Peroxidation, DNA Damage, NF(kappa)B Activation and TNF-alpha Proportional to Release in Macrophages. [R] . Leonard, S. S., Wang, S., Shi, X., 2000

机译：木材烟雾颗粒产生自由基并导致脂质过氧化，DNa损伤，NF（κ）B活化和TNF-α在巨噬细胞中释放的比例。

Oxidative damage shifts from lipid peroxidation to thiol arylation by catechol-containing antioxidants.

摘要

著录项

相似文献

相关主题

期刊订阅