...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Brain tumor pathology >Prognostic implication of p27 expression in primary central nervous system lymphoma
【24h】

Prognostic implication of p27 expression in primary central nervous system lymphoma

机译：p27表达在原发性中枢神经系统淋巴瘤中的预后意义

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To clarify the role of p27/Kipl (p27) in primary central nervous system lymphomas (PCNSLs), we examined p27 expression by immunohistochemical methods in a series of 22 patients with PCNSL. We attempted to correlate the expression of p27 with proliferation potential and prognosis. Although the MIB-1 labeling index (LI) was lower in tumors with low p-27 expression (26.7% +- 17.2% vs 38.1% +- 16.3%), it was not significantly different from that of tumors with high p27 expression (P = 0.1253). Survival analysis revealed that high p27 expression was significantly associated with poorer overall prognosis (P = 0.0011); however, the MIB-1 LI were not associated with prognosis. Our results suggest p27 as a predictor of prognosis in patients with PCNSL.
机译：为了阐明p27 / Kipl（p27）在原发性中枢神经系统淋巴瘤（PCNSLs）中的作用，我们通过免疫组化方法检查了22例PCNSL患者中p27的表达。我们试图将p27的表达与增殖潜能和预后相关联。尽管在低p-27表达的肿瘤中MIB-1标记指数（LI）较低（26.7％+-17.2％对38.1％+-16.3％），但与高p27表达的肿瘤没有显着差异（ P = 0.1253）。生存分析显示，高p27表达与较差的总体预后显着相关（P = 0.0011）;但是，MIB-1 LI与预后无关。我们的结果表明，p27可作为PCNSL患者预后的预测指标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号