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首页> 外文期刊>Artificial Organs >Clinical efficacy and biocompatibility of three different leukocyte and fat removal filters during cardiac surgery.
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Clinical efficacy and biocompatibility of three different leukocyte and fat removal filters during cardiac surgery.

机译：心脏手术中三种不同的白细胞和脂肪去除过滤器的临床疗效和生物相容性。

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摘要

Activated leukocytes and fat particles are associated with organ injury after a cardiac surgery. Filters are currently used to remove either leukocytes or fat particles. A novel approach with a filter that combines leukocyte and fat removal might be clinically useful. As it is not known which type of filter has a good and safe performance in both leukocyte and fat removal, we measured in this study the leukocyte and fat removal properties and the biocompatibility of three different filters. We used six Pall RS1 (Pall, Portsmouth, England) leukocyte removal filters, six Pall LipiGuard fat removal filters, and six Fresenius Biofil 02 (Fresenius, Emmer-Compascuum, The Netherlands) leukocyte removal filters and measured the passage times of 500 and 1000 mL of residual heart-lung machine blood. We determined the circulating leukocyte and platelet counts, and total hemoglobin, triglyceride, and free fatty acid concentration after the filters. In addition, we measured free hemoglobin, plasma elastase (Merck, Darmstadt, Germany), and complement C5-9 (Quidel, San Diego, CA, U.S.A.) to assess the biocompatibility of the filters. The circulating fat particles were calculated with an automated hematology analyzer. The passage time for the blood was shortest for the Biofil filter (P = 0.02, analysis of variance). The total leukocyte counts (P = 0.04) and fat particles (P = 0.02) were higher after the LipiGuard filter. This filter also had a higher increase in free hemoglobin concentration (P 0.03). We conclude that the leukocyte removal filters were superior to the fat removal filter both in leukocyte and fat removal.
机译：心脏手术后，活化的白细胞和脂肪颗粒与器官损伤有关。过滤器目前用于去除白细胞或脂肪颗粒。具有结合白细胞和脂肪去除的过滤器的新方法可能在临床上有用。由于尚不清楚哪种类型的过滤器在白细胞和脂肪去除方面均具有良好和安全的性能，因此我们在本研究中测量了三种不同过滤器的白细胞和脂肪去除特性以及生物相容性。我们使用了六个Pall RS1（Pall，英国朴茨茅斯）白细胞去除过滤器，六个Pall LipiGuard脂肪去除过滤器和六个Fresenius Biofil 02（Fresenius，Emmer-Compascuum，荷兰）去除白细胞，并测量了500和1000的通过时间毫升残留的心肺机血。我们确定了过滤后的循环白细胞和血小板计数，以及总血红蛋白，甘油三酸酯和游离脂肪酸的浓度。另外，我们测量了游离血红蛋白，血浆弹性蛋白酶（Merck，达姆施塔特，德国）和补体C5-9（Quidel，圣地亚哥，加利福尼亚，美国），以评估滤膜的生物相容性。用自动血液分析仪计算循环脂肪颗粒。 Biofil过滤器的血液通过时间最短（P = 0.02，方差分析）。使用LipiGuard过滤器后，白细胞总数（P = 0.04）和脂肪颗粒（P = 0.02）更高。该过滤器的游离血红蛋白浓度也更高（P 0.03）。我们得出的结论是，白细胞去除过滤器在白细胞去除和脂肪去除方面均优于脂肪去除过滤器。

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