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首页> 外文期刊>Artificial Organs >Complexity of Anti-immunosenescence Strategies in Humans.
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Complexity of Anti-immunosenescence Strategies in Humans.

机译：人类抗免疫衰老策略的复杂性。

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Immunosenescence is characterized by three main aspects: (i) the shrinkage of the T cell repertoire and the accumulation of oligoclonal expansions (megaclones) of memory/effector cells directed toward ubiquitary infectious agents; (ii) the involution of the thymus and the exhaustion of naive T cells; and (iii) a chronic inflammatory status called inflamm-aging. We present here possible strategies to counteract these main aspects of immunosenescence in humans with particular attention to the reduction of antigenic load by pathogens, such as CMV, and the normalization of intestinal microflora, the possible utilization of IL-7 to reverse thymic involution, the purging of megaclones, the forced expression of CD28 on T lymphocytes, the reduction of inflamm-aging and the administration of nutrients such as vitamin D. Possible drawbacks of all these strategies are discussed. Finally, the complexity of a rejuvenation approach is stressed, with particular attention to the inhibitory role played by the "old microenvironment" on the performance of progenitor cells, the best candidate to counteract the decline in regenerative potential characteristic of organs and tissues from old organisms.
机译：免疫衰老的特征在于三个主要方面：（i）T细胞库的缩小和记忆/效应细胞针对普遍存在的感染因子的寡克隆扩展（兆克隆）的积累; （ii）胸腺的退化和幼稚T细胞的衰竭; （iii）称为发炎衰老的慢性炎症状态。我们在这里提出抵消人类免疫衰老的这些主要方面的可能策略，尤其要注意降低病原体（例如CMV）的抗原负荷和肠道菌群的正常化，IL-7逆转胸腺退化的可能利用，清除大克隆，在T淋巴细胞上强制表达CD28，减少炎症衰老和施用营养素（例如维生素D）。讨论了所有这些策略的可能弊端。最后，强调了复兴方法的复杂性，尤其要注意“旧微环境”对祖细胞性能的抑制作用，这是抵消旧生物器官和组织再生潜能特征下降的最佳人选。 。

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