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首页> 外文期刊>Artificial Organs >Osteogenic induction of adipose-derived stromal cells: not a requirement for bone formation in vivo.
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Osteogenic induction of adipose-derived stromal cells: not a requirement for bone formation in vivo.

机译：成骨诱导脂肪基质细胞的诱导：不需要在体内形成骨。

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Osteogenic induction was regarded as an indispensable step for adipose-derived stromal cells (ADSCs) to have osteogenic ability. Non-induced ADSCs can also produce bone in vivo and heal skeletal defects. The present study aimed to compare the bone-forming ability of osteogenically induced ADSCs and non-induced ADSCs in vivo. Tissue-engineered constructs were prepared from osteogenically induced or non-induced ADSCs and porous hydroxyapatite/beta-tricalcium phosphate scaffolds. A scaffold without cells and an empty defect group were used as control. All were implanted in rat critical calvarial defects. After implantation for 6 and 12 weeks, bone formation was analyzed using histomorphometry and microcomputed tomography; there were no significant differences in the formation of new bone between osteogenically induced ADSCs and non-induced ADSCs (P > 0.05). In conclusion, osteogenic induction of ADSCs is not an indispensable step for bone formation in vivo. Non-induced ADSCs can also be used as seeding cells to construct bone tissue.
机译：成骨诱导被认为是脂肪来源的基质细胞（ADSC）具有成骨能力的必不可少的步骤。非诱导的ADSC也可以在体内产生骨骼并治愈骨骼缺损。本研究旨在比较成骨诱导的ADSC和非诱导的ADSC在体内的成骨能力。组织工程构建体由成骨诱导或非诱导ADSC和多孔羟基磷灰石/β-磷酸三钙支架制备而成。使用无细胞支架和空缺损组作为对照。所有这些都植入了大鼠的关键颅盖缺损。植入6周和12周后，使用组织形态计量学和显微计算机断层摄影术分析骨形成。成骨诱导的ADSC和非诱导的ADSC之间新骨的形成没有显着差异（P> 0.05）。总而言之，ADSCs的成骨诱导并不是体内骨骼形成必不可少的步骤。非诱导的ADSC也可以用作种子细胞以构建骨组织。

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