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Artificial Oxygen Carriers-A Clinical Point of View

机译:人工氧气载体-临床观点

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Artificial oxygen carriers (AOCs) as blood substitutes have long been studied as a projected shortage of blood or blood products appears imminent .Although it is desirable that AOCs will resolve current problems and assuage future concerns, the replacement of red blood cells (RBCs) represents a major hurdle , perhaps comparable with the complexities of the development of artificial heart or blood vessels; none of them have yet successfully replaced native tissues/organs. The situation is even less favorable for AOCs as transfusion medicine has been well established and is much more successful than any other organ/tissue transplantation. Although recent reports suggesting deterioration of donated blood after 2 weeks of storage may propel quests for AOCs, the synthesis of human hemoglobin (Hb) remains far behind the efficiency of blood donation.
机译:长期以来人们一直在研究作为血液替代品的人工氧气载体(AOC),因为预计即将出现血液或血液制品短缺。尽管希望AOC能够解决当前的问题并缓解未来的担忧,但替换红血球(RBC)代表了一个重大障碍,也许可以与人造心脏或血管发育的复杂程度相提并论;它们还没有成功替代天然组织/器官。这种情况对AOC来说甚至更加不利,因为输血医学已经很成熟,并且比任何其他器官/组织移植都成功得多。尽管最近的报告表明,储存2周后献血的恶化可能会推动对AOC的追求,但人类血红蛋白(Hb)的合成仍远远落后于献血的效率。

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