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Bone engineering: combining smart biomaterials and the application of stem cells.

机译：骨工程：将智能生物材料与干细胞的应用相结合。

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Remarkable preclinical progress and achievements in the isolation and characterization of stem cells from different sources have been made, together with the ability to control proliferation and differentiation in vitro. Researchers and physicians pin their hope on stem cells to develop novel approaches in regenerative medicine. Stem cell therapy is no longer a scientific discipline in the laboratory or in animal models only, as it is already performed routinely in the human therapeutical and clinical treatment for hematological malignancies and clinical trials for bone repair. It has further been recognized that angiogenesis plays a pivotal role for the successful transplantation of in vitro engineered tissues like bone structures, for the repair of large bone defects to facilitate engraftment. We intended to generate transplantable composite grafts, which consist of in vitro generated bone tissue from multipotent adult progenitor cells, maintaining an angiogenic potential to ease and optimize a successful engraftment of long-term sustainable and viable bone tissue. The other component was generated from several synthetically produced three-dimensional tissues like fibrin, thrombin, collagen, hydroxyapatite, and beta-tricalciumphosphate in different compositions and concentrations, all mimicking natural body structures of bone tissue as biocompatible grafts. We established an in vitro mouse model, using bone marrow and peripheral blood-derived murine progenitor cells as well as industrially manufactured materials generating composite grafts. Based on our preliminary results, we propose to pursue research on composite grafts for an extended graft survival and successful engraftment of transplanted tissue.
机译：在从不同来源分离和鉴定干细胞方面已经取得了明显的临床前进展和成就，以及在体外控制增殖和分化的能力。研究人员和医师将希望寄托在干细胞上，以开发再生医学的新方法。干细胞疗法不再只是实验室或动物模型中的科学学科，因为它已在血液恶性肿瘤的人类治疗和临床治疗以及骨修复的临床试验中常规进行。进一步认识到，血管生成对于成功移植体外工程化组织（如骨结构），修复大的骨缺损以促进植入起着关键作用。我们打算产生可移植的复合移植物，该移植物由多能成年祖细胞的体外生成的骨组织组成，保持血管生成的潜力，以缓解和优化长期可持续和可行的骨组织的成功植入。其他成分是由几种合成产生的三维组织（如血纤蛋白，凝血酶，胶原蛋白，羟基磷灰石和β-磷酸三钙）产生的，它们的成分和浓度不同，都模仿了骨组织的自然生物结构，成为生物相容性移植物。我们建立了一个体外小鼠模型，使用了骨髓和外周血来源的鼠祖细胞，以及使用工业生产的材料生成了复合移植物。基于我们的初步结果，我们建议继续研究复合材料移植物，以延长移植物的存活时间并成功植入被移植的组织。

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