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首页> 外文期刊>Artificial Organs >Hemodynamic support with the pulsatile catheter pump in a sheep model of acute heart failure.
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Hemodynamic support with the pulsatile catheter pump in a sheep model of acute heart failure.

机译：在急性心力衰竭的绵羊模型中，脉动导管泵对血流动力学的支持。

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This study was aimed to mimic clinical heart failure (HF) conditions and to assess the effect of pulsatilecatheter (PUCA) pump support on hemodynamics and tissue perfusion in a sheep model of acute HF. In 14 sheep, HF was induced by partial occluding the middle left circumflex coronary artery combined with pacemaker-induced tachycardia. PUCA pump was then activated to support the HF for 3 h. Hemodynamic parameters were recorded at baseline, HF, and then every 30 min during experiments. Blood samples were taken in carotid artery (CA), pulmonary artery (PA), and coronary sinus (CS) for the determination of oxygen saturation (SO(2)) and lactate concentration as markers of tissue perfusion. Results showed that HF model was induced successfully in 10 sheep and failed in four sheep due to refractory ventricular fibrillation. PUCA pump support was successful in seven out of 10 sheep for 3 h. Three cases failed due to technical problems. After HF (n = 10), cardiac output (CO) was decreased from 3.7 +/- 0.5 to 2.0 +/- 0.5 L/min (P < 0.001). Mean arterial pressure (MAP) was lowered from 116.1 +/- 14.2 to 68.1 +/- 14.7 mm Hg (P < 0.001). In seven sheep supported with PUCA pump, MAP rose from 68.9 +/- 15.2 to 94.7 +/- 14.7 mm Hg (P = 0.005), systolic blood pressure increased from 86.6 +/- 17.0 to 112.6 +/- 17.1 mm Hg (P = 0.009), and diastolic blood pressure increased from 57.7 +/- 12.6 to 79.9 +/- 13.9 mm Hg (P = 0.011). CO remained at about 2.0 L/min. SO(2) in CA, PA, and CS decreased significantly after HF (P < 0.001), with an increase after support (compared with HF, P < 0.001, 0.066 and 0.114, respectively). Lactate concentrations increased gradually in CA, PA, and CS toward the end of experiments without difference among different sampling sites. This HF model in sheep is simple, easy to manipulate, reproducible and reflecting clinical HF conditions. PUCA pump can maintain the hemodynamic status for 3 h in this acute HF model.
机译：这项研究旨在模拟临床心力衰竭（HF）状况，并评估脉动导管（PUCA）泵支持对急性HF绵羊模型的血流动力学和组织灌注的影响。在14只绵羊中，HF是通过部分闭塞左中旋支冠状动脉结合起搏器诱发的心动过速而诱发的。然后激活PUCA泵以支持HF 3小时。血流动力学参数记录在基线，HF，然后在实验期间每30分钟记录一次。在颈动脉（CA），肺动脉（PA）和冠状窦（CS）中采集血样，以确定血氧饱和度（SO（2））和乳酸浓度作为组织灌注的标志。结果表明，由于难治性心室纤颤，成功在10只绵羊中成功诱导了HF模型，而在4只绵羊中成功诱导了HF模型的失败。在10头羊中有7头成功使用PUCA泵支持了3小时。由于技术问题，三起案件失败。 HF（n = 10）后，心输出量（CO）从3.7 +/- 0.5降到2.0 +/- 0.5 L / min（P <0.001）。平均动脉压（MAP）从116.1 +/- 14.2毫米汞柱降低到68.1 +/- 14.7毫米汞柱（P <0.001）。在使用PUCA泵支撑的七只绵羊中，MAP从68.9 +/- 15.2毫米汞柱升至94.7 +/- 14.7毫米汞柱（P = 0.005），收缩压从86.6 +/- 17.0毫米汞柱升高至112.6 +/- 17.1毫米汞柱（P = 0.009），舒张压从57.7 +/- 12.6 mm Hg增加到79.9 +/- 13.9 mm Hg（P = 0.011）。 CO保持在约2.0L / min。 HF后，CA，PA和CS中的SO（2）显着降低（P <0.001），支持后有所增加（分别与HF，P <0.001、0.066和0.114相比）。在实验结束时，CA，PA和CS中的乳酸浓度逐渐增加，不同采样点之间没有差异。绵羊的HF模型简单，易于操作，可重现并反映临床HF情况。在这种急性HF模型中，PUCA泵可以维持3小时的血液动力学状态。

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