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首页> 外文期刊>Artificial Organs >Interaction of an idealized cavopulmonary circulation with mechanical circulatory assist using an intravascular rotary blood pump.
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Interaction of an idealized cavopulmonary circulation with mechanical circulatory assist using an intravascular rotary blood pump.

机译：理想的腔肺循环与使用血管内旋转血泵的机械循环辅助的相互作用。

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摘要

This study evaluated the performance of an intravascular, percutaneously-inserted, axial flow blood pump in an idealized total cavopulmonary connection (TCPC) model of a Fontan physiology. This blood pump, intended for placement in the inferior vena cava (IVC), is designed to augment pressure and blood flow from the IVC to the pulmonary circulation. Three different computational models were examined: (i) an idealized TCPC without a pump; (ii) an idealized TCPC with an impeller pump; and (iii) an idealized TCPC with an impeller and diffuser pump. Computational fluid dynamics analyses of these models were performed to assess the hydraulic performance of each model under varying physiologic conditions. Pressure-flow characteristics, fluid streamlines, energy augmentation calculations, and blood damage analyses were evaluated. Numerical predictions indicate that the pump with an impeller and diffuser blade set produces pressure generations of 1 to 16 mm Hg for rotational speeds of 2000 to 6000 rpm and flow rates of 1 to 4 L/min. In contrast, for the same flow range, the model with the impeller only in the IVC demonstrated pressure generations of 1 to 9 mm Hg at rotational speeds of 10,000 to 12,000 rpm. Influence of blood viscosity was found to be insignificant at low rotational speeds with minimal performance deviation at higher rotational speeds. Results from the blood damage index analyses indicate a low probability for damage with maximum damage index levels less than 1% and maximum fluid residence times below 0.6 s. The numerical predictions further indicated successful energy augmentation of the TCPC with a pump in the IVC. These results support the continued design and development of this cavopulmonary assist device.
机译：这项研究在Fontan生理学的理想化全腔肺连接（TCPC）模型中评估了血管内，经皮插入的轴向流动血泵的性能。该血泵旨在放置在下腔静脉（IVC）中，旨在增加从IVC到肺循环的压力和血液流量。研究了三种不同的计算模型：（i）没有泵的理想TCPC; （ii）带有叶轮泵的理想TCPC; （iii）带有叶轮和扩散泵的理想TCPC。对这些模型进行了计算流体动力学分析，以评估各种模型在不同生理条件下的水力性能。评估了压力流特征，流体流线，能量增加计算和血液损伤分析。数值预测表明，带有叶轮和扩散器叶片组的泵在2000至6000 rpm的转速和1至4 L / min的流量下产生1至16 mm Hg的压力。相反，对于相同的流量范围，仅在IVC中带有叶轮的模型在10,000至12,000 rpm的转速下显示了1至9 mm Hg的压力产生。发现在低转速下血液粘度的影响微不足道，而在较高转速下的性能偏差最小。血液损害指数分析的结果表明，损害的可能性很小，最大损害指数低于1％，最大液体停留时间低于0.6 s。数值预测进一步表明在IVC中使用泵成功地增加了TCPC的能量。这些结果支持了这种腔肺辅助装置的持续设计和开发。

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