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Electrospinning approaches toward scaffold engineering-a brief overview.

机译：脚手架工程的静电纺丝方法-简要概述。

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摘要

Tissue engineering involves the in vitro seeding of cells onto scaffolds which assume the role of supporting cell adhesion, migration, proliferation, and differentiation, and which define the three-dimensional shape of the tissue to be engineered. Among the various types of scaffold architectures available, scaffolds based on nanofibers mimicking to a certain extent the structure of the extracellular matrix offer great advantages. Electrospinning is the technique of choice for the preparation of such scaffolds. Investigations have revealed that the nanofibrous structure promotes cell adhesion, proliferation, and differentiation. Parameters relevant for these processes such as fiber diameters, surface topology, porosity, mechanical properties, and the fibrous architecture of the scaffold can be controlled by electrospinning in a broad range.
机译：组织工程涉及将细胞体外接种到支架上，该支架承担支持细胞粘附，迁移，增殖和分化的作用，并定义了要工程改造的组织的三维形状。在可用的各种类型的支架结构中，基于在一定程度上模拟细胞外基质结构的纳米纤维的支架具有很大的优势。电纺丝是制备此类支架的选择技术。研究表明，纳米纤维结构促进细胞粘附，增殖和分化。与这些过程相关的参数，例如纤维直径，表面拓扑，孔隙率，机械性能和支架的纤维结构，可以通过广泛的电纺丝来控制。

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