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Numerical Estimation of Hemolysis From the Point of View of Signal and System

机译：从信号和系统角度看溶血作用的数值估计

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The power-law based models for predicting shear-induced hemolysis are widely used in the optimization design of blood-contacting devices. However, this category of models has fallen short of accuracy when compared with the results of the in vitro experiments. The aim of this study is to develop an alternative model from the point of view of signal and system. Under the action of constant shear stress, the released hemoglobin was regarded as the output of system, and the system function that characterized the resistance to hemolysis was derived from the power-law equation. Two state variables were introduced to adequately capture the history of the system. The proposed model takes into account another known empirical formula, the threshold equation, by setting a nonzero initial condition of the blood. By comparing the estimated results with the published experimental data, it showed that the accuracy of the proposed model was notably improved. Furthermore, the analysis in frequency domain indicated that the damage contribution of the time-varying shear stress decreased with the increase of frequency. As the frequency domain analysis is important in many fields, it may play a role in the estimation of hemolysis in the future.
机译：基于幂律的模型预测剪切诱导的溶血被广泛用于血液接触设备的优化设计中。但是，与体外实验的结果相比，这类模型的准确性不足。这项研究的目的是从信号和系统的角度开发替代模型。在恒定剪应力的作用下，释放的血红蛋白被视为系统的输出，并从幂律方程中得出表征溶血性的系统功能。引入了两个状态变量以充分捕获系统的历史记录。提出的模型通过设置血液的非零初始条件，考虑了另一个已知的经验公式，即阈值方程。通过将估计结果与已发布的实验数据进行比较，表明所提出模型的准确性得到了显着提高。此外，频域分析表明，随频率增加，时变剪应力的破坏贡献减小。由于频域分析在许多领域都很重要，因此它可能在将来的溶血评估中发挥作用。

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