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Development of high-efficiency molecular adsorbent recirculating system: Preliminary report

机译：高效分子吸附剂再循环系统的开发：初步报告

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Molecular Adsorbent Recirculating System (MARS) is a liver support system widely employed in the treatment of liver failure. The method is normally well tolerated. To develop a liver support system combining high efficiency and tolerability, we modified the MARS albumin circuit with the insertion of double adsorption units in parallel. Four patients have been treated with this modified method (high-efficiency MARS, HE MARS): two had very high serum bilirubin and two had very high total bile acids. After a single MARS session bilirubin was reduced more with HE MARS than standard MARS (from 27.6 to 52.3% in patient A and from 27.9 to 49.1% in patient B), and bile acid reduction increased from 40 to 59.8% in patient C and from 39.9 to 60% in patient D. The results of this preliminary investigation in only a very small number of patients do support the possibility of developing a liver support system that combines good tolerability and high efficacy.
机译：分子吸附循环系统（MARS）是广泛用于肝功能衰竭治疗的肝脏支持系统。该方法通常耐受良好。为了开发结合了高效率和耐受性的肝脏支持系统，我们通过并行插入双吸附单元修改了MARS白蛋白回路。已经用这种改良方法治疗了四名患者（高效MARS，HE MARS）：两名患者的血清胆红素很高，而两名胆汁酸总量很高。在单次MARS疗程后，HE MARS的胆红素减少量较标准MARS减少更多（患者A从27.6降至52.3％，患者B从27.9降至49.1％），胆汁酸减少从患者C和40降至59.8％。 D患者中的39.9％至60％。仅在极少数患者中进行的这项初步研究的结果确实支持开发具有良好耐受性和高疗效的肝支持系统的可能性。

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