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A New Computational Fluid Dynamics Method for In-Depth Investigation of Flow Dynamics in Roller Pump Systems

机译：滚动泵系统流动动力学深入研究的一种新的计算流体动力学方法

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摘要

Roller pumps are commonly used in circulatory assist devices to deliver blood, but the inherent high mechanical stresses (especially wall shear stress) may cause considerable damage to cells. Conventional experimental approaches to evaluate and reduce device-induced cell damage require considerable effort and resources. In this work, we describe the use of a new computational fluid dynamics method to more effectively study roller pump systems. A generalized parametric model for the fluid field in a typical roller pump system is presented first, and analytical formulations of the moving boundary are then derived. Based on the model and formulations, the dynamic geometry and mesh of the fluid field can be updated automatically according to the time-dependent roller positions. The described method successfully simulated the pulsing flow generated by the pump, offering a convenient way to visualize the inherent flow pattern and to assess shear-induced cell damage. Moreover, the highly reconfigurable model and the semiautomated simulation process extend the usefulness of the presented method to a wider range of applications. Comparison studies were conducted, and valuable indications about the detailed effects of structural parameters and operational conditions on the produced wall shear stress were obtained. Given the good consistency between the simulated results and the existing experimental data, the presented method displays promising potential to more effectively guide the development of improved roller pump systems which produce less mechanical damage to cells.
机译：滚子泵通常用于循环辅助设备中以输送血液，但是固有的高机械应力（尤其是壁剪切应力）可能会对细胞造成相当大的损害。评估和减少设备引起的细胞损伤的常规实验方法需要大量的努力和资源。在这项工作中，我们描述了使用新的计算流体动力学方法来更有效地研究滚子泵系统的方法。首先介绍了典型辊式泵系统中流场的通用参数模型，然后得出了运动边界的解析公式。基于该模型和公式，可以根据时间相关的滚子位置自动更新流场的动态几何形状和网格。所描述的方法成功地模拟了泵产生的脉冲流，为可视化固有流型和评估剪切诱导的细胞损伤提供了便利的方法。而且，高度可重新配置的模型和半自动化的仿真过程将所提出的方法的实用性扩展到了更广泛的应用范围。进行了比较研究，并获得了有关结构参数和操作条件对产生的壁切应力的详细影响的有价值的指示。考虑到模拟结果与现有实验数据之间的良好一致性，所提出的方法显示出有希望的潜力，可以更有效地指导改进的滚筒泵系统的开发，该系统对电池的机械损伤较小。

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