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Modularity in developmental biology and artificial organs: a missing concept in tissue engineering.

机译:发育生物学和人工器官中的模块化:组织工程学中一个缺失的概念。

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摘要

Tissue engineering is reviving itself, adopting the concept of biomimetics of in vivo tissue development. A basic concept of developmental biology is the modularity of the tissue architecture according to which intermediates in tissue development constitute semiautonomous entities. Both engineering and nature have chosen the modular architecture to optimize the product or organism development and evolution. Bioartificial tissues do not have a modular architecture. On the contrary, artificial organs of modular architecture have been already developed in the field of artificial organs. Therefore the conceptual support of tissue engineering by the field of artificial organs becomes critical in its new endeavor of recapitulating in vitro the in vivo tissue development.
机译:组织工程学正在自我复兴,它采用了体内组织发育的仿生学概念。发育生物学的基本概念是组织结构的模块化,根据该模块化,组织发育中的中间体构成半自治实体。工程和自然界都选择了模块化架构来优化产品或有机体的发展和进化。生物人工组织没有模块化的体系结构。相反,模块化结构的人造器官已经在人造器官的领域中被开发。因此,人工器官领域对组织工程的概念性支持在其体外概括体内组织发育的新努力中变得至关重要。

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