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首页> 外文期刊>Artificial Organs >In vitro comparison of peracetic Acid and bleach cleaning of polysulfone hemodialysis membranes.
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In vitro comparison of peracetic Acid and bleach cleaning of polysulfone hemodialysis membranes.

机译：过氧乙酸和漂白剂清洗聚砜血液透析膜的体外比较。

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Dialyzer reuse has been employed throughout the history of hemodialysis, but the practice remains controversial. Many studies have found changes in the beta(2)-microglobulin clearance for reused dialyzers, but it is difficult to draw quantitative conclusions from the clinical data. The objective of this study was to quantitatively compare the effects of bleach and peracetic acid cleaning on the clearance and surface charge characteristics of Fresenius F80B polysulfone dialyzers (Fresenius Medical Care, Lexington, MA, USA). Clearance experiments were performed using urea, vitamin B(12), and polydisperse dextrans, with data obtained before and after exposure to human plasma in an in vitro dialysis circuit. Dialyzers cleaned with peracetic acid had significantly lower clearance of the larger dextrans due to the presence of residual protein on or within the membrane. Bleach was able to remove this protein deposit, restoring the clearance characteristics, but there was a significant increase in the net negative charge of the membrane due to chemical reaction with the bleach. In addition, longer time exposure to bleach altered the membrane transport characteristics, increasing the solute clearance. These results provide important insights into the effects of bleach and peracetic acid on the properties of the F80B dialyzers.
机译：在整个血液透析的历史中，都使用过透析器的重复使用，但是这种做法仍存在争议。许多研究发现重复使用透析器的β（2）-微球蛋白清除率发生了变化，但很难从临床数据中得出定量结论。这项研究的目的是定量比较漂白和过氧乙酸清洗对费森尤斯F80B聚砜透析器的清洁度和表面电荷特性的影响（美国马萨诸塞州列克星敦市的费森尤斯医疗公司）。使用尿素，维生素B（12）和多分散右旋糖酐进行清除实验，并获得了在体外透析回路中暴露于人体血浆之前和之后的数据。由于膜上或膜内残留蛋白质的存在，用过氧乙酸清洗过的透析器对较大的葡聚糖的清除率明显较低。漂白剂能够除去这种蛋白质沉积物，恢复了清除特性，但是由于与漂白剂发生化学反应，膜的净负电荷显着增加。此外，长时间接触漂白剂会改变膜的传输特性，从而增加溶质的清除率。这些结果为了解漂白剂和过乙酸对F80B透析器性能的影响提供了重要的见识。

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