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首页> 外文期刊>Artificial Organs >Uremic pruritus, cytokines, and polymethylmethacrylate artificial kidney.
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Uremic pruritus, cytokines, and polymethylmethacrylate artificial kidney.

机译：尿毒症瘙痒症，细胞因子和聚甲基丙烯酸甲酯人工肾。

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Uremic pruritus is one of the common complications in long-term dialysis patients. Recently, researchers reported that immunohypothesis with high serum level of cytokines could be the cause of uremic pruritus. Polymethylmethacrylate (PMMA) artificial kidney (AK) has been reported to adsorb more serum cytokines than other high-flux AKs. In July 2006, 30 patients with severe uremic pruritus from 300 chronic hemodialysis (HD) patients in a single center entered this prospective study. Their dialyzers were changed to PMMA AK for 4 weeks. The severity of pruritus was evaluated every week using the results of a questionnaire (pruritus score). Laboratory assays including predialysis serum blood urea nitrogen (BUN), creatinine, beta2-microglobulin (beta2M), calcium, phosphate, intact parathyroid hormone (iPTH), total CO(2), ferritin, hematocrit, high-sensitivity C-reactive protein (hsCRP), IL-1beta, IL-2, IL-6, IL-18, tumor necrosis factor-alpha (TNF-alpha), Kt/V, and beta2M clearance were measured before and at the end of 4 weeks of PMMA AK use. PMMA AK was effective in reducing the pruritus score from 23.46 +/- 11.94 to 7.38 +/- 6.42 (P < 0.001). The effect of uremic pruritus relief appeared after 1 week of PMMA AK use. There were no significant differences in the laboratory assay results including predialysis serum BUN, Cr, beta2M, calcium, phosphate, calcium-phosphate product, iPTH, total CO(2), ferritin, hematocrit, hsCRP, IL-1beta, IL-2, IL-6, IL-18, TNF-alpha, Kt/V, and beta2M clearance. The mechanism for the beneficial effect of PMMA AK on uremic pruritus remains to be determined. PMMA AK may be a useful adjuvant therapy in chronic HD patients with severe uremic pruritus.
机译：尿毒症瘙痒是长期透析患者的常见并发症之一。最近，研究人员报告说，血清细胞因子水平高的免疫假说可能是尿毒症瘙痒的原因。据报道，与其他高通量AK相比，聚甲基丙烯酸甲酯（PMMA）人工肾（AK）吸收更多的血清细胞因子。 2006年7月，来自一个中心的300例慢性血液透析（HD）患者中的30例严重尿毒症瘙痒患者进入了这项前瞻性研究。他们的透析器更换为PMMA AK，历时4周。每周使用问卷调查结果评估瘙痒的严重程度（瘙痒评分）。实验室检测包括透析前血清尿素氮（BUN），肌酐，β2-微球蛋白（beta2M），钙，磷酸盐，完整甲状旁腺激素（iPTH），总CO（2），铁蛋白，血细胞比容，高敏感性C反应蛋白（ hsCRP），IL-1beta，IL-2，IL-6，IL-18，肿瘤坏死因子-α（TNF-alpha），Kt / V和beta2M清除率在PMMA AK的4周之前和结束时进行了测量用。 PMMA AK可有效将瘙痒症评分从23.46 +/- 11.94降低至7.38 +/- 6.42（P <0.001）。 PMMA AK使用1周后出现尿毒症瘙痒缓解的效果。实验室检测结果包括透析前血清BUN，Cr，beta2M，钙，磷酸盐，磷酸钙产品，iPTH，总CO（2），铁蛋白，血细胞比容，hsCRP，IL-1beta，IL-2， IL-6，IL-18，TNF-α，Kt / V和beta2M清除率。 PMMA AK对尿毒症瘙痒有益作用的机制尚待确定。对于患有严重尿毒症瘙痒的慢性HD患者，PMMA AK可能是有用的辅助治疗。

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