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Animal Experiments of the Helical Flow Total Artificial Heart

机译：螺旋流全人工心脏的动物实验

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Severe cardiac failure patients require a total artificial heart (TAH) to save life. To realize a TAH that can fit a body of small stature and has high performance, high durability, good anatomical fitting, good blood compatibility, and physiological control, we have been developing the helical flow TAH (HFTAH) with two helical flow pumps with hydrodynamic levitation impeller. Animal experiments of the HFTAH were conducted to perform in vivo studies. The HFTAH was implanted in 13 adult female goats weighing 45.0-64.0kg. After surgery, neither anti-coagulant nor anti-platelet medication was given systemically. The HFTAH was usually driven with a quasi-pulsatile mode. The 1/R control or P control was applied to control the circulation. The P control is a new method using simplified equation of the 1/R control. The HFTAH could be implanted in all goats with good anatomical fitting. Two goats survived for a long time (100 and 68 days). Major causes of termination were device failure and surgical complications. In the device failure, trouble with hydrodynamic bearing was conspicuous. In the two long-term survived goats, experiments were terminated with bearing instability that was probably caused by the suction effect. In these goats, hemolysis occurred on postoperative day 88 and 44, which was considered to be relevant to the bearing trouble. Thrombus was found at the broken right bearing of the 100-day survived goat. However, antithrombogenicity of the pump is expected to be good unless bearing trouble occurs. In two long-term survived goats, the 1/R control or P control worked appropriately to prevent the elevation of right atrial pressure. In both goats, hemodynamic parameters changed with the condition of the animals, liver and kidney functions remained almost normal except when recovering from surgery and during hemolysis, and total protein recovered 2 weeks after surgery. Although instability of the hydrodynamic bearing should be improved, performance of the HFTAH with physiological control could be demonstrated.
机译：严重的心力衰竭患者需要总人工心脏（TAH）才能挽救生命。为了实现适合身材矮小的身体，具有高性能，高耐用性，良好的解剖学适应性，良好的血液相容性和生理控制性的TAH，我们已经开发了带有两个具有流体动力的螺旋流泵的螺旋流TAH（HFTAH）悬浮叶轮。进行HFTAH的动物实验以进行体内研究。将HFTAH植入13只成年雌性山羊，重45.0-64.0kg。手术后，既未全身性给予抗凝药也未给予抗血小板药。 HFTAH通常以准脉冲模式驱动。应用1 / R控制或P控制来控制循环。 P控制是一种使用1 / R控制的简化公式的新方法。 HFTAH可以植入所有具有良好解剖结构的山羊。两只山羊存活了很长时间（100天和68天）。终止的主要原因是设备故障和手术并发症。在设备故障中，动压轴承的故障很明显。在两只长期存活的山羊中，实验因轴承不稳定而终止，这可能是由吸力作用引起的。在这些山羊中，溶血发生在术后第88和44天，这被认为与轴承问题有关。在存活100天的山羊的右轴承破裂处发现血栓。但是，除非出现轴承故障，否则预期泵的抗血栓形成性会很好。在两只长期存活的山羊中，1 / R对照或P对照可以有效地防止右心房压力升高。在这两只山羊中，血液动力学参数随动物状况而变化，除了从手术中恢复和溶血期间，肝脏和肾脏功能几乎保持正常，并且在手术后2周恢复了总蛋白。尽管应该改善流体动力轴承的不稳定性，但是可以证明具有生理控制的HFTAH的性能。

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