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首页> 外文期刊>Artificial Organs >A novel device for reducing hemolysis provoked by cardiotomy suction during open heart cardiopulmonary bypass surgery: a randomized prospective study.
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A novel device for reducing hemolysis provoked by cardiotomy suction during open heart cardiopulmonary bypass surgery: a randomized prospective study.

机译：一种新颖的减少心脏直跳体外循环手术中因心脏切开术引起的溶血的设备：一项随机前瞻性研究。

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Since the inception of cardiopulmonary bypass (CPB), little progress has been made concerning the design of cardiotomy suction (CS). Because this is a major source of hemolysis, we decided to test a novel device (Smartsuction [SS]) specifically aimed at minimizing hemolysis during CPB in a clinical setting. Block randomization was carried out on a treated group (SS, n=28) and a control group (CTRL, n=26). Biochemical parameters were taken pre-, peri-, and post CPB and were compared between the two groups using the Student's t-test with statistical significance when P<0.05. No significant differences in patient demographics were observed between the two groups. Lactate dehydrogenase (LDH) and plasma free hemoglobin (PFH) pre-CPB were comparable for the CTRL and SS groups, respectively. LDH peri-CPB was 275+/-100 U/L versus 207+/-83 U/L for the CTRL and SS groups, respectively (P<0.05). PFH was 486+/-204 mg/L versus 351+/-176 mg/L for the CTRL and SS groups, respectively (P<0.05). LDH post CPB was 354+/-116 U/L versus 275+/-89 U/L for the CTRL and SS groups, respectively (P<0.05). PFH was 549+/-271 mg/L versus 460+/-254 mg/L for the CTRL and SS groups, respectively (P<0.05). Preoperative hematocrit (Hct) of 43+/-5% (CTRL) versus 37+/-5% (SS), and hemoglobin (Hb) of 141+/-16 g/L (CTRL) versus 122+/-17 g/L (SS) were significantly lower in the SS group. However, when normalized (N), the SS was capable of conserving Hct, Hb, and erythrocyte count perioperatively. Erythrocytes (N) were 59+/-5% (CTRL) versus 67+/-9% (SS); Hct (N) was 59+/-6% (CTRL) versus 68+/-9% (SS), and Hb (N) was 61+/-6% (CTRL) versus 70+/-10% (SS) (all P<0.05). This novel SS device evokes significantly lowered blood PFH and LDH values peri- and post CPB compared with the CTRL blood using a CS system. The SS may be a valuable alternative compared to traditional CS techniques.
机译：自从开始体外循环（CPB）以来，关于心脏切开吸引术（CS）的设计进展甚微。因为这是溶血的主要来源，所以我们决定测试一种新型设备（Smartsuction [SS]），该设备旨在在临床环境中最大程度地减少CPB期间的溶血。在治疗组（SS，n = 28）和对照组（CTRL，n = 26）上进行分组随机化。在CPB之前，之后和之后获取生化参数，并使用Student's t检验比较两组之间的生化参数，当P <0.05时，具有统计学意义。两组之间的患者人口统计学无显着差异。乳酸脱氢酶（LDH）和无血浆血红蛋白（PFH）的CPB分别与CTRL和SS组相当。 LDH外周血CPB为275 +/- 100 U / L，而CTRL和SS组分别为207 +/- 83 U / L（P <0.05）。 PFH为486 +/- 204 mg / L，而CTRL和SS组分别为351 +/- 176 mg / L（P <0.05）。 CPB后的LDH为354 +/- 116 U / L，而CTRL和SS组分别为275 +/- 89 U / L（P <0.05）。 PFH为549 +/- 271 mg / L，而CTRL和SS组分别为460 +/- 254 mg / L（P <0.05）。术前血细胞比容（Hct）为43 +/- 5％（CTRL）对37 +/- 5％（SS），血红蛋白（Hb）为141 +/- 16 g / L（CTRL）对122 +/- 17 g SS组的/ L（SS）明显较低。但是，当归一化（N）时，SS能够在围手术期保留Hct，Hb和红细胞计数。红细胞（N）为59 +/- 5％（CTRL）对67 +/- 9％（SS）; Hct（N）为59 +/- 6％（CTRL）对68 +/- 9％（SS），Hb（N）为61 +/- 6％（CTRL）对70 +/- 10％（SS） （所有P <0.05）。与使用CS系统的CTRL血液相比，这种新颖的SS设备可显着降低CPB前后的血液PFH和LDH值。与传统的CS技术相比，SS可能是有价值的选择。

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