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首页> 外文期刊>Artificial Organs >Study on decellularized porcine aortic valve/poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) hybrid heart valve in sheep model.
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Study on decellularized porcine aortic valve/poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) hybrid heart valve in sheep model.

机译：绵羊模型中脱细胞猪主动脉瓣/聚（3-羟基丁酸酯-co-3-羟基己酸酯）混合心脏瓣膜的研究。

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摘要

To overcome shortcomings of current heart valve prostheses, novel hybrid valves were fabricated from decellularized porcine aortic valves coated with poly (3-hydroxybutyrate-co-3-hydroxyhexanoate [PHBHHx]). In the mechanical test in vitro, the biomechanical performance of hybrid valve was investigated. In an in vivo study, hybrid valve conduits were implanted in pulmonary position in sheep without cardiopulmonary bypass. Uncoated grafts were used as control. The valves were explanted and examined histologically and biochemically 16 weeks after surgery. The hybrid valve conduits maintained original shapes, were covered by a confluent layer of cells, and had less calcification than uncoated control. The mechanical test in vitro revealed that PHBHHx coating improved tensile strength. The results in vivo indicated that PHBHHx coating reduced calcification and promoted the repopulation of hybrid valve with the recipient's cells resembling native valve tissue. The hybrid valve may provide superior valve replacement with current techniques.
机译：为了克服当前心脏瓣膜假体的缺点，由涂覆有聚（3-羟基丁酸酯-co-3-羟基己酸酯[PHBHHx]）的脱细胞的猪主动脉瓣制成了新型的混合瓣膜。在体外力学测试中，研究了混合阀的生物力学性能。在一项体内研究中，在没有体外循环的情况下，将混合瓣膜导管植入了绵羊的肺部位置。未涂覆的移植物用作对照。术后16周将瓣膜移出并进行组织学和生化检查。混合阀导管保持原始形状，被汇合的细胞层覆盖，钙化程度低于未涂覆的对照。体外机械测试表明，PHBHHx涂层改善了拉伸强度。体内结果表明，PHBHHx涂层减少了钙化并促进了混合瓣膜的重新繁殖，其中受体细胞类似于天然瓣膜组织。混合阀可以通过当前技术提供卓越的阀替代。

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