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首页> 外文期刊>Artificial Organs >Coated carbon hemoperfusion provides limited clearance of protein-bound solutes.
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Coated carbon hemoperfusion provides limited clearance of protein-bound solutes.

机译：涂层碳血液灌流提供了有限的蛋白质结合溶质清除率。

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摘要

This study assessed the capacity of a cartridge containing coated granular carbon to clear protein-bound solutes. Clearances for test solutes were measured while an albumin solution representing plasma was pumped from a 10 L reservoir through the cartridge at a rate of 200 mL/min for 5 h. Clearance values for phenol red, phenytoin, and indican were well below the limit imposed by the plasma flow and declined with time. The clearance of phenol red, which was the most tightly bound solute, fell from 38 +/- 12 to 17 +/- 2 mL/min. Additional studies revealed that the cartridge contained enough carbon to absorb all the protein-bound test solutes, but that the rate of their clearance was limited by the inability of granular carbon to take up solutes rapidly at a low concentration. The rate of solute uptake at low concentration was shown to be much greater when carbon was in powdered rather than granular form. A device in which approximately 50 g of powdered carbon was recirculated in the dialysate compartment of hollow fiber kidneys cleared phenol red and phenytoin more rapidly than the hemoperfusion cartridge containing 300 g of coated granular carbon. These results indicate that hemoperfusion over coated granular carbon provides limited clearance of protein-bound solutes.
机译：这项研究评估了装有涂层颗粒碳的弹药筒清除结合蛋白的溶质的能力。当代表血浆的白蛋白溶液以200 mL / min的速度从10 L储罐中通过泵抽出5 h时，测试溶质的清除率。酚红，苯妥英钠和靛蓝的清除率值远低于血浆流量所施加的极限，并随时间下降。最紧密结合的溶质酚红的清除率从38 +/- 12降至17 +/- 2 mL / min。进一步的研究表明，药筒中的碳足以吸收所有与蛋白质结合的测试溶质，但其清除速度受到颗粒状碳无法以低浓度快速吸收溶质的限制。当碳为粉末状而不是颗粒状时，低浓度下的溶质吸收率显示出更高的比率。一种装置，其中约50 g的粉末状碳在中空纤维肾脏的透析液室中再循环，比含有300 g涂层的颗粒状碳的血液灌流盒更快地清除了酚红和苯妥英。这些结果表明在包被的颗粒碳上的血液灌流提供了有限的蛋白质结合溶质清除率。

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