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首页> 外文期刊>Artificial Organs >Biomechanical properties of decellularized porcine pulmonary valve conduits.
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Biomechanical properties of decellularized porcine pulmonary valve conduits.

机译：去细胞猪肺动脉瓣导管的生物力学特性。

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摘要

Tissue-engineered heart valves constructed from a xenogeneic or allogeneic decellularized matrix might overcome the disadvantages of current heart valve substitutes. One major necessity besides effective decellularization is to preserve the biomechanical properties of the valve. Native and decellularized porcine pulmonary heart valve conduits (PPVCs) (with [n = 10] or without [n = 10] cryopreservation) were compared to cryopreserved human pulmonary valve conduits (n = 7). Samples of the conduit were measured for wall thickness and underwent tensile tests. Elongation measurement was performed with a video extensometer. Decellularized PPVC showed a higher failure force both in longitudinal (+73%; P < 0.01) and transverse (+66%; P < 0.001) direction compared to human homografts. Failure force of the tissue after cryopreservation was still higher in the porcine group (longitudinal: +106%, P < 0.01; transverse: +58%, P < 0.001). In comparison to human homografts, both decellularized and decellularized cryopreserved porcine conduits showed a higher extensibility in longitudinal (decellularized: +61%, P < 0.001; decellularized + cryopreserved: +51%, P < 0.01) and transverse (decellularized: +126%, P < 0.001; decellularized + cryopreserved: +118%, P < 0.001) direction. Again, cryopreservation did not influence the biomechanical properties of the decellularized porcine matrix.
机译：由异种或异体脱细胞基质构建的组织工程化心脏瓣膜可克服当前心脏瓣膜替代物的缺点。除了有效的脱细胞作用之外，最主要的需要之一就是保持瓣膜的生物力学特性。将天然和脱细胞的猪肺心瓣膜导管（PPVC）（有[n = 10]或没有[n = 10]冻存）与冻存的人肺动脉瓣导管（n = 7）进行了比较。测量导管样品的壁厚并进行拉伸测试。用视频引伸计进行伸长率测量。与人同种异体移植相比，脱细胞的PPVC在纵向（+ 73％; P <0.01）和横向（+ 66％; P <0.001）方向均显示出更高的破坏力。猪组冷冻保存后的组织破坏力仍然更高（纵向：+ 106％，P <0.01;横向：+ 58％，P <0.001）。与人同种异体移植相比，去细胞和去细胞的低温保存的猪导管在纵向（去细胞：+ 61％，P <0.001;去细胞+冷冻保存：+ 51％，P <0.01）和横向（去细胞：+ 126％）上均显示出更高的可扩展性。 ，P ＜0.001;去细胞+冷冻保存：+ 118％，P ＜0.001）方向。同样，冷冻保存不影响脱细胞猪基质的生物力学性能。

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